Journal of Pharmaceutical and Medical Research
type: channel
description: Journal of Pharmaceutical and Medical Research (JPMR) is an international peer-reviewed, open access journal.
publisher: UPub Science
language: en
publication name: Journal of Pharmaceutical and Medical Research
issn: 2663-1954
items: FROM GUT TO BRAIN: TARGETING THE MICROBIOTA AXIS FOR NOVEL THERAPEUTIC AVENUES IN PARKINSON’S DISEASE
items: EVALUATION OF PERFORMANCE AND SAFETY OF THE 12-LEAD ECG: A PROSPECTIVE SIMULTANEOUS PAIRED COMPARATIVE STUDY
items: TREM1 PROMOTES GASTRIC CANCER METASTASIS AND LEADS TO POOR PROGNOSIS IN PATIENTS THROUGH THE ERK/IL-6 SIGNALING PATHWAY
items: EXPRESSION AND CLINICAL SIGNIFICANCE OF LHPP IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA
items: PROGRESS AND MECHANISMS OF ANTIBODY-DRUG CONJUGATES IN NSCLC THERAPY
items: NURSING EFFECT OF TRADITIONAL CHINESE MEDICINE SMEARING ON RADIATION SKIN INJURY IN A PATIENT WITH BREAST CANCER
items: EFFICACY ANALYSIS OF ULTRASONIC DIAGNOSIS FOR SARCOPENIA IN PATIENTS IN THE INTENSIVE CARE UNIT
items: FACTORS INFLUENCING ENTERAL FEEDING INTOLERANCE IN NEUROCRITICAL PATIENTS BASED ON ADMISSION DATA
items: EXPRESSION AND CLINICAL SIGNIFICANCE OF GLYCEROL KINASE (GK) IN ESOPHAGEAL CARCINOMA
items: MECHANISM STUDY OF SHENFU INJECTION REGULATING MAPK PATHWAY TO ALLEVIATE MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RATS BASED ON BIOINFORMATICS AND EXPERIMENTAL VERIFICATION
items: ANALYSIS OF THE STATUS OF NEWLY REPORTED OCCUPATIONAL DISEASES IN EMPLOYING UNITS IN A CERTAIN CITY FROM 2015 TO 2024
items: THE ANIMAL MODEL ESTABLISHMENT METHODS AND MODEL EVALUATION FOR LIVER STAGNATION AND SPLEEN DEFICIENCY SYNDROME
items: REGRESSION ANALYSIS-BASED INVESTIGATION OF FACTORS INFLUENCING MALE FETAL Y CHROMOSOME CONCENTRATION AND STRATIFIED OPTIMIZATION OF OPTIMAL TIMING FOR NON-INVASIVE PRENATAL TESTING
items: NON-INVASIVE PRENATAL DETECTION MODEL FOR FEMALE FETAL CHROMOSOMAL ANEUPLOIDY BASED ON XGBOOST
items: MACROPHAGES IN ACUTE MYOCARDIAL INFARCTION: HETEROGENEITY AND TARGETED THERAPIES
items: THE EFFICACY OF ELECTROTHERAPY WITH BIAN STONE IN TREATING FUNCTIONAL CONSTIPATION IN THE ELDERLY
items: PRETREATMENT ULTRASOUND-BASED RADIOMICS NOMOGRAM FOR PREDICTING PATHOLOGICAL COMPLETE RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN HER2-POSITIVE BREAST CANCER
items: EXPRESSION AND PROGNOSTIC VALUE OF HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) AND VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGFC) IN NON-SMALL CELL LUNG CANCER
items: ADVANCES IN THE APPLICATION OF DEEP LEARNING IN CERVICAL OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT
items: POST-MARKET CLINICAL FOLLOW-UP STUDY OF THE COLOR DOPPLER ULTRASOUND SYSTEM: A PROSPECTIVE, COMPARATIVE EVALUATION OF SAFETY AND PERFORMANCE
items: RECENT ADVANCES IN THE NEUROPROTECTIVE EFFECTS OF TRADITIONAL CHINESE MEDICINE: FOCUS ON ACTIVE INGREDIENTS AND MECHANISMS OF ACTION IN ALZHEIMER’S DISEASE
items: OPTIMIZATION OF NIPT TIMING FOR MALE FETUSES AND ABNORMALITY DETECTION IN FEMALE FETUSES BASED ON QUALITY-CORRECTED MODELS
items: RESEARCH PROGRESS ON LONG NON-CODING RNA-MEDIATED SEPSIS PROGRESSION
items: THE CORRELATION BETWEEN LIFESTYLE AND PREVALENCE OF KNEE JOINT DISEASE IN PLATEAU AREAS
items: EARLY VERSUS DELAYED INTERVENTIONAL EMBOLIZATION FOR RUPTURED ANTERIOR COMMUNICATING ARTERY ANEURYSMS: A SINGLE-CENTER RETROSPECTIVE COHORT STUDY OF 22 CASES WITH LITERATURE REVIEW
items: EFFECT OF NPC1 AS AN INDEPENDENT RISK FACTOR ON THE PROGNOSIS OF CERVICAL CANCER
items: ANALYSIS OF PRESCRIPTION PATTERNS OF TRADITIONAL CHINESE MEDICINE FORMULAS FOR STROKE TREATMENT
items: ANALYSIS OF THE EFFECT OF ARTIFICIAL INTELLIGENCE-ASSISTED MINIMALLY INVASIVE TREATMENT FOR URINARY CALCULI
items: ESTABLISHMENT OF A METHOD FOR MONITORING MEROPENEM CONCENTRATIONS IN PATIENTS WITH SEVERE ACUTE PANCREATITIS
items: MICRO-ADJUSTMENT MANIPULATION COMBINED WITH TRADITIONAL MANIPULATION FOR KNEE OSTEOARTHRITIS WITH VARUS DEFORMITY

FROM GUT TO BRAIN: TARGETING THE MICROBIOTA AXIS FOR NOVEL THERAPEUTIC AVENUES IN PARKINSON’S DISEASE
type: item
description: Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, with increasing evidence highlighting a strong link between its pathogenesis and intestinal microbiome dysbiosis. This review systematically elucidates the mechanistic pathways of the microbiota–gut–brain axis in PD, emphasizing how gut dysbiosis promotes α-synuclein misfolding and propagation via the vagus nerve, thereby initiating neuroinflammation and dopaminergic neuronal loss. It further examines the critical role of the microbiota–immune–neural signaling network in driving disease progression. In addition, the therapeutic potential and current limitations of microbiota-targeted interventions, including fecal microbiota transplantation, prebiotics, probiotics, and dietary modulation, are evaluated. Collectively, current evidence highlights the gut–brain axis as a key framework in understanding PD etiology and underscores the intestine as a promising site for early intervention and the development of mechanism-based therapies.
subject: Research Article
  topic: section
subject: Parkinson’s disease
  topic: keywords
subject: Gut microbiota
  topic: keywords
subject: α-synuclein
  topic: keywords
subject: Neurodegenerative disease
  topic: keywords
subject: Neuroinflammation
  topic: keywords
subject: Microecological therapy
  topic: keywords
creator: ShengLi Gu
rights: Copyright (c) 2026 ShengLi Gu https://creativecommons.org/licenses/by/4.0
date: 2026-03-09
publication date: 2026-03-09
starting page: 47
ending page: 50
doi: 10.61784/jpmr3066

EVALUATION OF PERFORMANCE AND SAFETY OF THE 12-LEAD ECG: A PROSPECTIVE SIMULTANEOUS PAIRED COMPARATIVE STUDY
type: item
description: This prospective, paired comparative study aimed to evaluate the diagnostic accuracy and safety of a multi-channel digital ECG system (Zoncare company, E-Series) against a conventional device (ED** company, SE-Series) in a clinical setting. A total of 154 participants were categorized into three groups—normal ECG, arrhythmia, and ST-segment elevation/depression—and underwent sequential ECG recordings with both devices in randomized order. Key parameters, including heart rate, PR interval, QRS duration, QT interval, and the axes of the P wave, QRS complex, and T wave, and ST-segment deviation, were automatically measured by both systems, with ST-deviation also assessed manually. Results indicated no statistically significant differences (P > 0.05) in any parameter between the two devices. Manual evaluation confirmed 100% recognition accuracy of ST-segment elevation or depression by the E-Series, with no significant difference in deviation magnitude (P > 0.05). Automatic measurements exhibited exceptionally high inter-device correlation, with r-values approaching 1 (all P < 0.001). No device-related adverse events were recorded throughout the study. In conclusion, the Zoncare E-Series multi-channel digital ECG system demonstrated diagnostic non-inferiority compared to the conventional reference device across a spectrum of cardiac rhythms and ischemic manifestations, supporting its reliability and safety for clinical electrocardiographic acquisition.
subject: Research Article
  topic: section
subject: Accuracy
  topic: keywords
subject: Electrocardiograph
  topic: keywords
subject: Multichannel
  topic: keywords
subject: ECG parameters
  topic: keywords
subject: ST-segment deviation
  topic: keywords
subject: Arrhythmias
  topic: keywords
subject: Safety
  topic: keywords
creator: Bo Zhang
creator: Tao Zhu
creator: Tao Hu
creator: Jing Li
creator: JiaBing Zhu
creator: ZiYan Wan
rights: Copyright (c) 2026 Bo Zhang; Tao Zhu; Tao Hu; Jing Li; JiaBing Zhu; ZiYan Wan https://creativecommons.org/licenses/by/4.0
date: 2026-02-02
publication date: 2026-02-02
starting page: 21
ending page: 27
doi: 10.61784/jpmr3063

TREM1 PROMOTES GASTRIC CANCER METASTASIS AND LEADS TO POOR PROGNOSIS IN PATIENTS THROUGH THE ERK/IL-6 SIGNALING PATHWAY
type: item
description: Objective: To analyze the expression of TREM1 in gastric cancer tissues and serum of gastric cancer patients, and to explore the link between TREM1 expression levels and the clinical features of patients. Furthermore, to explore the specific mechanism by which TREM1 promotes the metastatic ability of MKN45 cells. Method: Gene expression analysis, differential genes, KEGG enrichment analysis, and immune correlation analysis were performed using TCGA and GEO databases; Compare the concentration of TREM1 in the serum of gastric cancer patients using clinical serum sample standards and group them to analyze the relationship between TREM1 and clinical characteristics and prognosis of patients; Select MKN45 cells, silence the expression of TREM1 and IL-6 using small interfering RNA, overexpress TREM1 using plasmid, and perform corresponding treatments. Compare the changes in cell proliferation and migration ability in different groups using scratch assay and transwell assay; Western blotting was used to detect changes in the ERK signaling pathway, IL-6 expression, and EMT related proteins among different groups; Real time fluorescence quantitative PCR comparison of changes in downstream immune factors of TREM1. Result: TREM1 concentration increased in the serum of gastric cancer patients and was associated with their recurrence, metastasis, and overall survival time; TREM1 promotes invasion and metastasis of MKN45 cells; TREM1 upregulates IL-6 by activating the ERK signaling pathway; TREM1 promotes gastric cancer EMT by upregulating IL-6, leading to enhanced metastatic ability of gastric cancer cells. Conclusion: TREM1 is highly expressed in the serum of gastric cancer patients and upregulates IL-6 by activating the ERK signaling pathway, thereby promoting EMT and invasion and metastasis of gastric cancer, leading to poor prognosis for patients.
subject: Research Article
  topic: section
subject: TREM1
  topic: keywords
subject: IL-6
  topic: keywords
subject: Gastric cancer
  topic: keywords
subject: EMT
  topic: keywords
subject: ERK signaling pathway
  topic: keywords
subject: Recurrence and metastasis
  topic: keywords
creator: ZhiGang Zhai
creator: Yuan Fang
creator: ZhenYu Xue
creator: Jian Guo
creator: Wen Sun
creator: Xiang Tang
rights: Copyright (c) 2026 ZhiGang Zhai; Yuan Fang; ZhenYu Xue; Jian Guo; Wen Sun; Xiang Tang https://creativecommons.org/licenses/by/4.0
date: 2026-01-09
publication date: 2026-01-09
starting page: 8
ending page: 15
doi: 10.61784/jpmr3062

EXPRESSION AND CLINICAL SIGNIFICANCE OF LHPP IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA
type: item
description: Objective: To investigate the expression characteristics, clinical significance and underlying molecular mechanism of phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) in esophageal squamous cell carcinoma (ESCC), and to provide novel potential targets for the diagnosis, prognostic evaluation and clinical treatment of ESCC. Methods: The expression difference of LHPP mRNA between ESCC tissues and adjacent normal tissues was analyzed from the Gene Expression Omnibus (GEO) database including GSE20347, GSE38129 and GSE77861. A total of 15 pairs of ESCC tumor tissues and matched adjacent normal tissues, serum samples from 40 newly diagnosed ESCC patients and 20 healthy volunteers were collected. The expression level of LHPP was detected by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). Western blot was used to determine the protein expression of LHPP in ESCC cell lines (TE-1, KYSE-30, KYSE-150) and the normal esophageal epithelial cell line Het-1A. The correlation between LHPP expression and survival prognosis of ESCC patients was analyzed based on The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) between LHPP high and low expression groups were screened, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The characteristics of tumor-infiltrating immune cells, the expression profiles of immune checkpoint genes and the sensitivity to five clinical common chemotherapeutic drugs including paclitaxel were further detected and compared between the two groups. Results: LHPP was significantly down-regulated in ESCC tissues, peripheral serum of ESCC patients and ESCC cell lines (P<0.05). ESCC patients with low LHPP expression had a markedly shortened median survival time (1.5 years vs 2.8 years), and the area under the curve (AUC) values of LHPP for predicting the 1-year, 2-year and 3-year overall survival rates of ES…
subject: Research Article
  topic: section
subject: Esophageal squamous cell carcinoma
  topic: keywords
subject: LHPP
  topic: keywords
subject: Tumor suppressor gene
  topic: keywords
subject: Tumor immune microenvironment
  topic: keywords
subject: Chemotherapeutic sensitivity
  topic: keywords
subject: Prognostic marker
  topic: keywords
creator: ZhiGang Zhai
creator: Yuan Fang
creator: ZhenYu Xue
creator: Jian Guo
creator: Xiang Tang
rights: Copyright (c) 2026 ZhiGang Zhai; Yuan Fang; ZhenYu Xue; Jian Guo; Xiang Tang https://creativecommons.org/licenses/by/4.0
date: 2026-03-06
publication date: 2026-03-06
starting page: 37
ending page: 46
doi: 10.61784/jpmr3065

PROGRESS AND MECHANISMS OF ANTIBODY-DRUG CONJUGATES IN NSCLC THERAPY
type: item
description: Antibody–drug conjugates (ADCs) are emerging as a transformative therapeutic modality for non-small cell lung cancer (NSCLC), bridging the tumor selectivity of monoclonal antibodies with the potent cytotoxicity of chemotherapy payloads. This review summarizes recent clinical progress of ADCs in NSCLC and highlights key design features that shape efficacy and safety, including antigen selection, linker chemistry, payload class, drug–antibody ratio, and the bystander effect. Particular emphasis is placed on clinically advanced targets—HER2, TROP2, HER3, and MET—as well as promising emerging antigens such as B7-H3. Across multiple studies, next-generation ADCs have shown meaningful activity in molecularly defined and treatment-refractory populations, including patients with acquired resistance to EGFR-targeted therapy and those harboring HER2 alterations. However, ADC use is constrained by distinctive toxicities, notably interstitial lung disease/pneumonitis associated with certain topoisomerase I inhibitor payloads, alongside myelosuppression and gastrointestinal adverse events. We further discuss evolving resistance mechanisms (antigen downregulation, impaired internalization, efflux transporters, and microenvironmental barriers) and outline future directions, including biomarker-guided patient selection, rational sequencing, and combination strategies with immune checkpoint inhibitors or targeted agents. Collectively, ADCs are poised to become an integral component of precision therapy for NSCLC, contingent on optimized design and proactive toxicity management.
subject: Research Article
  topic: section
subject: Antibody-drug conjugates
  topic: keywords
subject: ADCs
  topic: keywords
subject: NSCLC
  topic: keywords
creator: XiangYu Jia
creator: YunLong Yang
rights: Copyright (c) 2026 XiangYu Jia; YunLong Yang https://creativecommons.org/licenses/by/4.0
date: 2026-02-13
publication date: 2026-02-13
starting page: 28
ending page: 36
doi: 10.61784/jpmr3064

NURSING EFFECT OF TRADITIONAL CHINESE MEDICINE SMEARING ON RADIATION SKIN INJURY IN A PATIENT WITH BREAST CANCER
type: item
description: This article summarized the nursing effect and experience of a case of skin injury caused by radiotherapy of breast cancer treated with Chinese herbal medicine. Diyu has the effects of cooling blood, stopping bleeding, antibacterial, anti allergic, anti-inflammatory, reducing swelling, antioxidant, improving the blood system and neuroprotection. Diyu ointment is applied to the site of radiation-induced skin injury through traditional Chinese medicine rubbing, and has achieved good results. The patient's site has healed well and is very satisfied with the treatment effect. This ointment has a single ingredient and good therapeutic effect, and can be used by radiation therapy patients for the prevention and treatment of radiation-induced skin damage.
subject: Research Article
  topic: section
subject: Traditional Chinese Medicine application
  topic: keywords
subject: Breast cancer
  topic: keywords
subject: Radiation induced skin damage
  topic: keywords
subject: Nursing
  topic: keywords
creator: XiaoYan Wen
creator: XiuLing Ding
creator: YaLin Guo
creator: Jin Liu
creator: LiLi Jia
rights: Copyright (c) 2026 XiaoYan Wen; XiuLing Ding; YaLin Guo; Jin Liu; LiLi Jia https://creativecommons.org/licenses/by/4.0
date: 2026-01-12
publication date: 2026-01-12
starting page: 16
ending page: 20
doi: 10.61784/jpmr3060

EFFICACY ANALYSIS OF ULTRASONIC DIAGNOSIS FOR SARCOPENIA IN PATIENTS IN THE INTENSIVE CARE UNIT
type: item
description: Objective: To Explore the Efficacy of Ultrasound in Diagnosing Sarcopenia in the Intensive Care Unit (ICU)Introduction: Critically ill patients with sarcopenia experience prolonged mechanical ventilation duration, extended hospital stay, and increased mortality. Ultrasound is characterized by convenience, radiation-free nature, and low cost in the ICU setting; however, few studies have investigated its efficacy in diagnosing sarcopenia among ICU patients. Methods: The skeletal muscle area at the third lumbar vertebra (L3 SMA) was calculated by analyzing abdominal computed tomography (CT) images acquired at the time of patient admission. Ultrasound was used to scan the cross-sectional area (RFCSA) and thickness (RFMT) of the rectus femoris muscle in the patients’ right lower limbs. With CT as the gold standard, a diagnostic study was conducted to evaluate the efficacy of ultrasound in diagnosing sarcopenia in ICU patients. Results: Among the 366 enrolled patients, regardless of gender, those with sarcopenia had lower values of age, body mass index (BMI), L3 SMA, RFCSA, and RFMT compared with patients without sarcopenia. For the diagnosis of sarcopenia in ICU patients using ultrasound-measured RFCSA, the area under the curve (AUC) was 0.794 in males and 0.766 in females. When using ultrasound-measured RFMT for diagnosis, the AUC was 0.791 in males and 0.736 in females. The combined use of these two ultrasound parameters further improved the diagnostic efficacy. Conclusion: Ultrasound can serve as a reliable method for sarcopenia screening in ICU patients.
subject: Research Article
  topic: section
subject: ICU
  topic: keywords
subject: Ultrasound
  topic: keywords
subject: Sarcopenia
  topic: keywords
subject: Diagnostic efficacy
  topic: keywords
creator: ShiPing Wang
rights: Copyright (c) 2025 ShiPing Wang https://creativecommons.org/licenses/by/4.0
date: 2025-12-05
publication date: 2025-12-05
starting page: 44
ending page: 49
doi: 10.61784/jpmr3055

FACTORS INFLUENCING ENTERAL FEEDING INTOLERANCE IN NEUROCRITICAL PATIENTS BASED ON ADMISSION DATA
type: item
description: Objective: To identify risk factors for feeding intolerance (FI) among neurocritical patients based on admission data.Methods: A retrospective study was conducted using convenience sampling to analyze neurocritical patients who were admitted to the neurology department of a tertiary hospital in Suzhou and received enteral nutrition between January 2018 and December 2022. Univariate and multivariate logistic regression analyses were performed to determine independent predictors of FI.Results: A total of 291 patients were included, of whom 119 (40.9%) developed FI. Univariate analysis showed that age, history of diabetes, history of stroke, Glasgow Coma Scale (GCS) score, and Nutritional Risk Screening 2002 (NRS-2002) score were significantly associated with FI (P<0.05). Multivariate logistic regression identified history of diabetes (OR=2.687), history of stroke (OR=2.352), lower GCS score (OR=0.750), and higher NRS-2002 score (OR=1.467) as independent risk factors for FI.Conclusion: History of diabetes, history of stroke, lower GCS score, and higher NRS-2002 score are major risk factors for FI in neurocritical patients. Early identification of these high-risk characteristics using admission data may support timely, targeted interventions to improve feeding tolerance and enhance the effectiveness of enteral nutrition.
subject: Research Article
  topic: section
subject: Neurocritical patients
  topic: keywords
subject: Enteral nutrition
  topic: keywords
subject: Feeding intolerance
  topic: keywords
subject: Nursing
  topic: keywords
creator: ZhongYi Wu
rights: Copyright (c) 2025 ZhongYi Wu https://creativecommons.org/licenses/by/4.0
date: 2025-12-11
publication date: 2025-12-11
starting page: 56
ending page: 60
doi: 10.61784/jpmr3057

EXPRESSION AND CLINICAL SIGNIFICANCE OF GLYCEROL KINASE (GK) IN ESOPHAGEAL CARCINOMA
type: item
description: Objective: This study aimed to investigate the expression of glycerol kinase (GK) in esophageal carcinoma tissues and cell lines, and to explore its correlation with clinical characteristics and patient prognosis. Methods: Public databases (TCGA, GTEx) and clinical specimens were used to validate GK expression in esophageal carcinoma tissues. The KYSE150 cell line was selected for GK knockdown experiments. Cell proliferation and migration were assessed using CCK-8 and Transwell assays, respectively. R language was employed to analyze correlations between GK expression and immune checkpoint molecules, as well as the tumor immune microenvironment. Results: GK mRNA and protein expression levels were significantly elevated in esophageal carcinoma tissues compared to adjacent normal tissues. Patients with high GK expression had significantly shorter overall survival than those with low expression. Clinical analysis revealed that high GK expression was strongly associated with distant metastasis and tumor recurrence. In vitro experiments demonstrated that GK knockdown suppressed proliferation and migration of esophageal carcinoma cells. Bioinformatic analysis indicated that high GK expression correlated with upregulation of immune checkpoint molecules (e.g., CD274, CTLA4, LAG3) and reduced infiltration of CD8+ T cells. Conclusion: GK is highly expressed in esophageal carcinoma and promotes malignant progression by enhancing tumor cell proliferation, migration, and participation in an immunosuppressive microenvironment. GK may serve as a potential prognostic biomarker and therapeutic target.
subject: Research Article
  topic: section
subject: GK
  topic: keywords
subject: ESCA
  topic: keywords
subject: Immune microenvironment
  topic: keywords
subject: Survival prognosis
  topic: keywords
creator: Yuan Fang
creator: ZhenYu Xue
creator: Jian Guo
creator: Wen Sun
creator: Xiang Tang
rights: Copyright (c) 2026 Yuan Fang; ZhenYu Xue; Jian Guo; Wen Sun; Xiang Tang https://creativecommons.org/licenses/by/4.0
date: 2026-01-09
publication date: 2026-01-09
starting page: 1
ending page: 7
doi: 10.61784/jpmr3061

MECHANISM STUDY OF SHENFU INJECTION REGULATING MAPK PATHWAY TO ALLEVIATE MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RATS BASED ON BIOINFORMATICS AND EXPERIMENTAL VERIFICATION
type: item
description: To elucidate SFI’s protective mechanism against MIRI, this study identified the MAPK pathway via bioinformatics. Experimental validation in MIRI rats confirmed that SFI improves myocardial injury by suppressing MAPK activation and inflammatory factors (IL-1β, IL-6, TNF-α), supporting its clinical potential.
subject: Research Article
  topic: section
subject: Shenfu Injection (SFI)
  topic: keywords
subject: Myocardial Ischemia-Reperfusion Injury (MIRI)
  topic: keywords
subject: Mitogen-Activated Protein Kinase (MAPK) signaling pathway
  topic: keywords
subject: Bioinformatics
  topic: keywords
subject: Inflammatory factors
  topic: keywords
creator: Hong Wang
creator: Liu Yang
creator: HuaiGang Chen
creator: GaoMing Hong
creator: ShengQiang Zeng
creator: WenYan Xu
creator: Yao Hu
rights: Copyright (c) 2025 Hong Wang; Liu Yang; HuaiGang Chen; GaoMing Hong; ShengQiang Zeng; WenYan Xu; Yao Hu https://creativecommons.org/licenses/by/4.0
date: 2025-11-14
publication date: 2025-11-14
starting page: 15
ending page: 19
doi: 10.61784/jpmr3048

ANALYSIS OF THE STATUS OF NEWLY REPORTED OCCUPATIONAL DISEASES IN EMPLOYING UNITS IN A CERTAIN CITY FROM 2015 TO 2024
type: item
description: Objective: To analyze the epidemiological characteristics and trends of newly reported occupational diseases among employing units in a certain City from 2015 to 2024, and to provide a scientific basis for developing targeted occupational disease prevention and control strategies. Methods: A retrospective epidemiological investigation was conducted. Data from 469 newly reported occupational disease cases in a certain City between 2015 and 2024 were collected from the occupational disease reporting system. Descriptive epidemiological methods and statistical analyses (chi-square test, analysis of variance) were employed to analyze the distribution characteristics and trends of occupational diseases. Results: Pneumoconiosis was the predominant occupational disease in a certain City, accounting for 95.10% of all cases. Among these, coal workers' pneumoconiosis (316 cases, 67.38%) and silicosis (130 cases, 27.72%) were the most common. The year 2019 marked the peak incidence (89 cases), with a fluctuating downward trend observed in recent years. A significant difference was found in the average length of exposure before onset among different occupational diseases (F = 11.41, P = 0.001), with coal workers' pneumoconiosis having the longest average exposure period (25.66 ± 6.63 years). Conclusions: While certain achievements have been made in occupational disease prevention and control in a certain City, pneumoconiosis remains the primary concern. Targeted prevention and control measures should be strengthened in high-risk areas and industries, and for specific exposure length groups. Additionally, emerging occupational health risks require ongoing attention.
subject: Research Article
  topic: section
subject: Energy city
  topic: keywords
subject: Occupational diseases
  topic: keywords
subject: Incidence trend
  topic: keywords
creator: Wei Gao
creator: Yong Zhang
creator: Xin Ge
rights: Copyright (c) 2025 Wei Gao; Yong Zhang; Xin Ge https://creativecommons.org/licenses/by/4.0
date: 2025-11-26
publication date: 2025-11-26
starting page: 20
ending page: 24
doi: 10.61784/jpmr3051

THE ANIMAL MODEL ESTABLISHMENT METHODS AND MODEL EVALUATION FOR LIVER STAGNATION AND SPLEEN DEFICIENCY SYNDROME
type: item
description: The fast pace of modern life has increased stress, leading to a faster incidence of liver qi stagnation and spleen deficiency syndrome in diseases. Therefore, liver qi stagnation and spleen deficiency syndrome has become a common clinical syndrome. Animal models of liver qi stagnation and spleen deficiency syndrome are used in various disease areas, and numerous methods exist for evaluating these models, resulting in problems such as confusion regarding counter-evidence formulas. This article mainly evaluates the modeling methods, behavioral testing methods, and counter-evidence formulas for liver qi stagnation and spleen deficiency syndrome in various diseases, providing theoretical support for experimental research on this syndrome.
subject: Research Article
  topic: section
subject: Liver qi stagnation and spleen deficiency syndrome
  topic: keywords
subject: Animal model
  topic: keywords
subject: Counter-evidence formula
  topic: keywords
subject: Behavioral science
  topic: keywords
subject: Tail clamping
  topic: keywords
subject: Restraint
  topic: keywords
creator: Feng Wang
creator: HuiYong Zhang
creator: GuanLin Yang
rights: Copyright (c) 2025 Feng Wang; HuiYong Zhang; GuanLin Yang https://creativecommons.org/licenses/by/4.0
date: 2025-11-29
publication date: 2025-11-29
starting page: 25
ending page: 29
doi: 10.61784/jpmr3052

REGRESSION ANALYSIS-BASED INVESTIGATION OF FACTORS INFLUENCING MALE FETAL Y CHROMOSOME CONCENTRATION AND STRATIFIED OPTIMIZATION OF OPTIMAL TIMING FOR NON-INVASIVE PRENATAL TESTING
type: item
description: This study systematically analyzed the quantitative relationship between male fetal Y chromosome concentration and maternal gestational age and body mass index, aiming to optimize the timing for non-invasive prenatal testing. To investigate these relationships, gestational age data formats were standardized, and missing BMI values were calculated and imputed. Pearson and Spearman correlation analyses revealed a weak positive correlation between Weeks and, and a weak negative correlation with BMI. Further OLS regression modeling revealed that Weeks exerted a significant positive effect on Y and BMI a significant negative effect , both statistically significant. Although the linear model exhibited low explanatory power and heteroscedasticity, incorporating LOWESS nonlinear smoothing clearly revealed a “rapid-then-slow” increase pattern of Y with Weeks. This confirmed the clinical observation that Y significantly declines when BMI exceeds 30. Subsequently, to determine the optimal testing window, pregnant women were stratified into four BMI groups. Intra-group OLS regression and LOWESS fitting were performed, supplemented by sensitivity analysis using 3.5%, 4.0%, and 4.5% thresholds. Results indicated that detection was feasible around 11–12 weeks for low-BMI women; while high-BMI pregnant women required delaying until approximately 12.5 weeks to achieve stable detection rates. This study provides quantitative evidence for optimizing NIPT testing strategies in clinical practice.
subject: Research Article
  topic: section
subject: Non-invasive prenatal testing
  topic: keywords
subject: Regression analysis
  topic: keywords
subject: Optimal testing timing
  topic: keywords
subject: Y Chromosome Concentration
  topic: keywords
creator: Ting Li
rights: Copyright (c) 2025 Ting Li https://creativecommons.org/licenses/by/4.0
date: 2025-12-03
publication date: 2025-12-03
starting page: 30
ending page: 37
doi: 10.61784/jpmr3053

NON-INVASIVE PRENATAL DETECTION MODEL FOR FEMALE FETAL CHROMOSOMAL ANEUPLOIDY BASED ON XGBOOST
type: item
description: Addressing the challenge of limited accuracy in non-invasive prenatal testing (NIPT) for female fetal chromosomal aneuploidy due to the absence of Y chromosome reference, this study innovatively proposes a multi-feature fusion detection model based on XGBoost. The model's innovations are threefold: first, it constructs a three-dimensional feature system integrating "Z-score-GC content-clinical indicators", breaking through the limitation of traditional methods relying on single chromosomal indicators; second, it leverages XGBoost's powerful capability in capturing nonlinear relationships to deeply explore complex interaction effects among multi-chromosomal features; third, through feature importance ranking, it systematically reveals for the first time the critical roles of GC content in chromosome 13 and Z-scores of chromosomes 18 and X in female fetal abnormality detection. Experimental results demonstrate that the model achieves an accuracy of 75.45%, precision of 75.63%, recall of 75.45%, and F1-score of 75.47%, significantly outperforming traditional methods. This study provides a novel technical approach for detecting female fetal chromosomal aneuploidy with substantial clinical application value.
subject: Research Article
  topic: section
subject: Non-Invasive prenatal testing
  topic: keywords
subject: Chromosomal aneuploidy
  topic: keywords
subject: XGBoost
  topic: keywords
subject: Feature fusion
  topic: keywords
subject: Female fetal detection
  topic: keywords
creator: RuiYing Chen
rights: Copyright (c) 2025 RuiYing Chen https://creativecommons.org/licenses/by/4.0
date: 2025-12-03
publication date: 2025-12-03
starting page: 38
ending page: 43
doi: 10.61784/jpmr3054

MACROPHAGES IN ACUTE MYOCARDIAL INFARCTION: HETEROGENEITY AND TARGETED THERAPIES
type: item
description: Cardiac repair after acute myocardial infarction depends on the precise regulation of the immune microenvironment. Macrophages are now understood beyond the M1/M2 dichotomy, with dual origins and a continuous functional spectrum. This review summarizes the spatiotemporal roles of cardiac resident and monocyte-derived macrophages, as well as their coordination in the resolution of inflammation, tissue repair, and scar maturation. It also outlines new therapeutic strategies targeting the recruitment of macrophages, their phenotypic transition, and metabolic reprogramming to improve post-infarction cardiac remodeling.
subject: Research Article
  topic: section
subject: Myocardial infarction
  topic: keywords
subject: Macrophages
  topic: keywords
subject: Ventricular remodeling
  topic: keywords
subject: Immunotherapy
  topic: keywords
creator: HaoDi Fu
creator: YiHuan Chen
rights: Copyright (c) 2025 HaoDi Fu; YiHuan Chen https://creativecommons.org/licenses/by/4.0
date: 2025-12-18
publication date: 2025-12-18
starting page: 61
ending page: 70
doi: 10.61784/jpmr3058

THE EFFICACY OF ELECTROTHERAPY WITH BIAN STONE IN TREATING FUNCTIONAL CONSTIPATION IN THE ELDERLY
type: item
description: Objective: The objective of the study is to assess the effect of a combined therapy of electric heating and Bian stone use with functional constipation in aged patients aiming to come up with a non-drug teaching method and to obtain a subjective reference of applying the intervention of traditional Chinese medicine non-drug to treat chronic diseases. Methods: Sixty-six elderly constipated patients were recruited notwithstanding the inclusion criteria. The patients were randomly split into a group of patients undergoing stone therapy and a control group (n=33 each) using Stata 15.1 software. Both conditions were treated to conventional monotherapy, using lactulose and glycerol suppositories, and the control group also had the pseudo clinical nursing care. Moreover, the Bian stone therapy group went through an extensive course of electrotherapy using Bian stones. This system involved the use of Chinese herbal medicine as a vehicle, the application of acupoints, and localized four energy methods, including rubbing, vibration, tapping, and warming. The treatment was done as 20 minutes per day during a 10-day course of the therapy. The scores of constipation symptoms were measured in both groups before the treatment and in day five and day ten. Symptomatic efficacy and quality of life were also observed by the time to the first bowel movement after treatment. Results: The overall efficacy rate of the stone treatment group, at the end of the treatment, was 93.94% which was much better than that of the control group, which was 54.84. Median time taken to pass bowel movement was 18hours in the stone therapy group and 34hours in the control group and the differences were statistically significant (P<0.01). Day 5 of treatment, both groups proved to have a significant improvement in the constipation symptom score levels with the stone therapy group proving better than the other in terms of the time to first bowel movement score, feeling of incomplete evacuation score, and the …
subject: Research Article
  topic: section
subject: Electro-heated stone therapy
  topic: keywords
subject: Elderly
  topic: keywords
subject: Functional constipation
  topic: keywords
subject: Non-pharmacological traditional Chinese medicine therapy
  topic: keywords
subject: Clinical efficacy
  topic: keywords
creator: Xia Li
creator: Fei Wang
creator: Yan Qin
creator: Erdi Wang
creator: Jie Zhang
rights: Copyright (c) 2025 Xia Li; Fei Wang; Yan Qin; Erdi Wang; Jie Zhang https://creativecommons.org/licenses/by/4.0
date: 2025-12-09
publication date: 2025-12-09
starting page: 50
ending page: 55
doi: 10.61784/jpmr3056

PRETREATMENT ULTRASOUND-BASED RADIOMICS NOMOGRAM FOR PREDICTING PATHOLOGICAL COMPLETE RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN HER2-POSITIVE BREAST CANCER
type: item
description: Background: Accurately predicting pathological complete response (PCR) to neoadjuvant chemotherapy (NAC) in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer is crucial for tailoring individualized treatment strategies. This study seeks to develop and validate a radiomics-based nomogram utilizing pretreatment ultrasound (US) data to predict PCR on an individual basis. Methods: In this retrospective analysis, patients diagnosed with HER2-positive breast cancer who underwent NAC were included and randomly assigned to either a training cohort (70%) or a validation cohort (30%) between January 2020 and December 2024. Radiomics features were extracted from the entire tumor volume as delineated on pretreatment US images. Feature selection was conducted using a combination of stability analysis, the Least Absolute Shrinkage and Selection Operator (LASSO)to establish a comprehensive radiomics signature (Rad-score). A predictive nomogram was then constructed by integrating the Rad-score with independent clinical predictors through multivariate logistic regression. The model's performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration curves, and decision curve analysis (DCA). Results:The radiomics signature, consisting of 10 features derived from first-order statistics and texture matrices, exhibited significant predictive capability, achieving an area under the curve (AUC) of 0.705 in the validation cohort. The final nomogram, integrating the Rad-score, progesterone receptor (PR), demonstrated enhanced performance, with AUCs of 0.749 and 0.744 in the training and validation cohorts, respectively. Calibration curves and decision curve analyses confirmed the model's robust calibration and clinical applicability. Conclusion: The pretreatment ultrasonography-based radiomics nomogram offers a non-invasive and effective tool for the individualized prediction of pathological complete response (PCR…
subject: Research Article
  topic: section
subject: Breast cancer
  topic: keywords
subject: HER2-Positive
  topic: keywords
subject: Neoadjuvant chemotherapy
  topic: keywords
subject: Ultrasonography
  topic: keywords
subject: Radiomics
  topic: keywords
subject: Machine learning
  topic: keywords
creator: FeiFei Shan
creator: JunQi Sun
creator: Wei Zhou
creator: ChengYuan Zheng
rights: Copyright (c) 2025 FeiFei Shan; JunQi Sun; Wei Zhou; ChengYuan Zheng https://creativecommons.org/licenses/by/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 71
ending page: 80
doi: 10.61784/jpmr3059

EXPRESSION AND PROGNOSTIC VALUE OF HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) AND VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGFC) IN NON-SMALL CELL LUNG CANCER
type: item
description: Non-small cell lung cancer (NSCLC) represents the most prevalent subtype of lung cancer, exhibiting high mortality rates globally. Identification of robust prognostic biomarkers is critical for early diagnosis, risk stratification, and the development of targeted therapies. Human epidermal growth factor receptor 2 (HER2) and vascular endothelial growth factor C (VEGFC) have been implicated in tumor proliferation, angiogenesis, and metastasis. However, their expression patterns and prognostic significance in NSCLC remain incompletely characterized. In this study, we performed a comprehensive bioinformatics analysis using publicly available datasets, including The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Oncomine, and Human Protein Atlas (HPA). Differential expression, clinical correlation, survival, immune infiltration, functional enrichment, and protein–protein interaction (PPI) analyses were conducted. Our results demonstrated that HER2 and VEGFC were significantly upregulated in NSCLC tissues compared to normal controls. Elevated expression of either gene was associated with advanced tumor stage, lymph node metastasis, and poor overall survival. Co-expression analysis indicated a synergistic negative impact on prognosis. Functional enrichment suggested involvement of HER2 in PI3K-Akt signaling and cell proliferation, while VEGFC was associated with lymphangiogenesis and vascular development. Immune infiltration analysis revealed significant correlations with CD8+ T cells, regulatory T cells, and macrophage populations. These findings suggest that HER2 and VEGFC serve as prognostic biomarkers and potential therapeutic targets in NSCLC, warranting further validation in clinical studies.
subject: Research Article
  topic: section
subject: Non-small cell lung cancer
  topic: keywords
subject: Human epidermal growth factor receptor 2
  topic: keywords
subject: Vascular endothelial growth factor C
  topic: keywords
creator: Lu Xu
rights: Copyright (c) 2025 Lu Xu https://creativecommons.org/licenses/by/4.0
date: 2025-11-13
publication date: 2025-11-13
starting page: 1
ending page: 8
doi: 10.61784/jpmr3050

ADVANCES IN THE APPLICATION OF DEEP LEARNING IN CERVICAL OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT
type: item
description: Cervical ossification of the posterior longitudinal ligament (OPLL) is relatively common among Asian populations. Its progression can cause spinal canal stenosis and compression of the spinal cord and nerve roots, leading to neurological dysfunction and increasing surgical complexity and the risk of complications. In recent years, early identification, precise evaluation, and appropriate intervention for OPLL have become major focuses in radiology and spine surgery. Artificial intelligence, particularly deep learning, has shown new potential in the detection, lesion segmentation, and prognostic evaluation of this disease. This article integrates existing studies to summarize the advances of deep learning in multimodal imaging and discusses its value in clinical decision support, aiming to provide methodological references and clinical insights for related disciplines.
subject: Research Article
  topic: section
subject: Deep learning
  topic: keywords
subject: Cervical ossification of the posterior longitudinal ligament
  topic: keywords
subject: Multimodal medical imaging
  topic: keywords
subject: Risk prediction
  topic: keywords
creator: ZhongLiang Wang
creator: Xiang Guo
rights: Copyright (c) 2025 ZhongLiang Wang; Xiang Guo https://creativecommons.org/licenses/by/4.0
date: 2025-11-13
publication date: 2025-11-13
starting page: 9
ending page: 14
doi: 10.61784/jpmr3049

POST-MARKET CLINICAL FOLLOW-UP STUDY OF THE COLOR DOPPLER ULTRASOUND SYSTEM: A PROSPECTIVE, COMPARATIVE EVALUATION OF SAFETY AND PERFORMANCE
type: item
description: Background: Post-market clinical follow-up (PMCF) studies are essential for verifying the real-world safety and performance of medical devices. This study evaluated the ViV 80 Color Doppler Ultrasound System (Zoncare) against the Model R**7 from a well-established manufacturer (M** company) in routine clinical practice. Methods: A prospective, observational, single-center study was conducted at Maternal and Child Health Hospital of Hubei Province, China. A total of 363 cases (140 male, 223 female) underwent abdominal, thyroid, cardiac, and gynecologic examinations using four probe types (convex, linear, phased array, volume). Endpoints included image consistency (target ≥95%), positive detection rate, and adverse events. Results: Image Consistency: All probes met the 95% target (convex: 97%; linear: 100%; phased array: 95%; volume: 96%). Moreover, mean image quality scores were consistently high, with the ViV 80 performing comparably or superiorly to the R**7 in each body site; Detection Rates: Varied by anatomy (liver: 44%; thyroid: 31%; cardiac: 8%; uterus: 26%), reflecting clinical heterogeneity; Adverse Events: No device-related adverse events occurred; five cases reported transient pressure sensations (1.4%). Conclusion: The ViV 80 demonstrated non-inferiority to the R** 7 in image quality and safety, supporting its continued use in diverse clinical applications.
subject: Research Article
  topic: section
subject: Color Doppler Ultrasound System
  topic: keywords
subject: Post-market clinical follow-up
  topic: keywords
subject: Safety
  topic: keywords
subject: Performance
  topic: keywords
subject: Image consistency
  topic: keywords
subject: MDR
  topic: keywords
subject: PMCF
  topic: keywords
subject: ViV 80
  topic: keywords
creator: Sheng Zhao
creator: FuCheng Wang
creator: Tao Hu
creator: Dan Wu
creator: JieBing Ma
creator: BaoLi Zhang
rights: Copyright (c) 2025 Sheng Zhao; FuCheng Wang; Tao Hu; Dan Wu; JieBing Ma; BaoLi Zhang https://creativecommons.org/licenses/by/4.0
date: 2025-09-25
publication date: 2025-09-25
starting page: 37
ending page: 43
doi: 10.61784/jpmr3044

RECENT ADVANCES IN THE NEUROPROTECTIVE EFFECTS OF TRADITIONAL CHINESE MEDICINE: FOCUS ON ACTIVE INGREDIENTS AND MECHANISMS OF ACTION IN ALZHEIMER’S DISEASE
type: item
description: Alzheimer's disease (AD) is a senile brain disease characterized by insidious onset and neurodegenerative pathology. According to reports from the World Health Organization, the global population of individuals affected by AD exceeds 55 million, with a new case occurring approximately every three seconds. This number is projected to exceed 150 million by the year 2050. Given the unclear pathogenesis of AD, there are currently no available etiological treatments. Traditional Chinese Medicine (TCM) is known for its multi-target therapeutic approach, which provides several advantages, including a variety of treatment methods, minimal side effects, and the capacity to coordinate effects across multiple targets and pathways. This makes TCM particularly significant for research focused on the prevention and treatment of AD. This paper utilizes TCM as a foundation to review recent research findings regarding its treatment of AD, including ganolearins A–D, ulmoidol (30), Ganoderma lucidum polysaccharide, Ganoderma sinense crude polysaccharide and so on . It identifies newly discovered active ingredients and treatment methods, with the aim of providing a theoretical basis for TCM approaches to AD and serving as a reference for drug development.
subject: Research Article
  topic: section
subject: Alzheimer's disease
  topic: keywords
subject: Traditional Chinese Medicine
  topic: keywords
subject: Active ingredient
  topic: keywords
subject: Mechanism of action
  topic: keywords
subject: Neuroprotection
  topic: keywords
creator: YiWen Zhang
rights: Copyright (c) 2025 YiWen Zhang https://creativecommons.org/licenses/by/4.0
date: 2025-10-20
publication date: 2025-10-20
starting page: 59
ending page: 65
doi: 10.61784/jpmr3047

OPTIMIZATION OF NIPT TIMING FOR MALE FETUSES AND ABNORMALITY DETECTION IN FEMALE FETUSES BASED ON QUALITY-CORRECTED MODELS
type: item
description: This study aims to enhance the accuracy of non-invasive prenatal testing (NIPT) by optimizing detection timing for male fetuses and improving abnormality diagnosis for female fetuses. For male fetuses, a multivariate nonlinear regression model quantified the associations of Y-chromosome fraction with gestational weeks and maternal BMI, revealing quadratic and decreasing trends, respectively. Ordered clustering and a risk-based optimization identified four BMI groups with distinct optimal testing windows, where higher BMI delayed the best timing. Monte Carlo simulations further confirmed sequencing quality as the main error source. For female fetuses, a combined logistic regression–random forest model was developed using standardized Z-scores and quality indicators, with an optimal diagnostic threshold (τ = 0.35). The resulting workflow integrates quality screening, Z-score assessment, probability evaluation, and BMI-specific correction. These models provide clinically interpretable guidance to improve NIPT reliability and prenatal decision-making.
subject: Research Article
  topic: section
subject: NIPT
  topic: keywords
subject: Nonlinear regression
  topic: keywords
subject: Ordered clustering
  topic: keywords
subject: Multi-objective optimization
  topic: keywords
subject: Female fetal abnormality detection
  topic: keywords
creator: ZhiJian Dai
creator: LinYv Yang
creator: Kun Li
creator: ZongSheng Wang
creator: YiFeng Liu
creator: JunRan Zhao
creator: Liang Xia
rights: Copyright (c) 2025 ZhiJian Dai; LinYv Yang; Kun Li; ZongSheng Wang; YiFeng Liu; JunRan Zhao; Liang Xia https://creativecommons.org/licenses/by/4.0
date: 2025-10-18
publication date: 2025-10-18
starting page: 52
ending page: 58
doi: 10.61784/jpmr3046

RESEARCH PROGRESS ON LONG NON-CODING RNA-MEDIATED SEPSIS PROGRESSION
type: item
description: Sepsis represents a severe dysregulation of the host response to infection. In recent years, the involvement of long non-coding RNAs (lncRNAs) in the onset and progression of sepsis has garnered significant attention. This review outlines the expression profiles and regulatory functions of lncRNAs in sepsis, emphasizing their associations with inflammatory processes, immune dysregulation, and organ injury. It highlights the molecular pathways through which lncRNAs influence sepsis by modulating inflammatory signaling, immune cell activities, and programmed cell death. Additionally, the potential utility of lncRNAs as diagnostic markers and therapeutic targets is discussed.
subject: Research Article
  topic: section
subject: Long non-coding RNA
  topic: keywords
subject: Sepsis
  topic: keywords
subject: Inflammatory response
  topic: keywords
subject: Immune regulation
  topic: keywords
subject: Organ injury
  topic: keywords
subject: Molecular mechanism
  topic: keywords
creator: HongYan Ren
creator: JianQuan Li
rights: Copyright (c) 2025 HongYan Ren; JianQuan Li https://creativecommons.org/licenses/by/4.0
date: 2025-08-28
publication date: 2025-08-28
starting page: 26
ending page: 30
doi: 10.61784/jpmr3041

THE CORRELATION BETWEEN LIFESTYLE AND PREVALENCE OF KNEE JOINT DISEASE IN PLATEAU AREAS
type: item
description: The high incidence of knee osteoarthritis (KOA) in the plateau has become an important public health issue . The unique geographical environment of the plateau has multiple impacts on the joint health of residents . Clinical studies have shown that the prevalence of knee osteoarthritis (KOA) in plateau residents is significantly higher than that in the plains, and can even be up to three times that of the plains. This difference is not only closely related to the special geographical and climatic conditions of the plateau, but also affected by the unique lifestyle of local residents . The combined effect of environmental factors and lifestyle has made knee joint diseases in this region appear younger and more severe. This article will systematically sort out the multidimensional research framework of the special geographical environment and lifestyle of the plateau and the prevalence of knee joint diseases from seven dimensions. The main contents are as follows: (1) Research background overview: Introducing the high incidence of plateau knee arthritis and its research value; (2) Geographical influence mechanisms: Analyze the mechanisms of high altitude, low oxygen, cold weather, and other factors, and use tables to compare data; (3) Special lifestyle influences: Explore the role of lifestyle factors such as working posture and diet structure; (4) Population distribution characteristics: Summarize the differences in prevalence by sex, age, and ethnicity, using comparative tables; (5) Disease characteristics and impact: Describe the clinical presentation, imaging features, and socioeconomic burden of the disease; (6) Prevention and treatment strategy recommendations: Propose a three-level prevention system and an “active health management” model; (7) Research Outlook: Point out the future research direction.
subject: Research Article
  topic: section
subject: Plateau area
  topic: keywords
subject: High Incidence of Knee Osteoarthritis (KOA)
  topic: keywords
creator: JianCheng Li
creator: NaNa Ma
rights: Copyright (c) 2025 JianCheng Li; NaNa Ma https://creativecommons.org/licenses/by/4.0
date: 2025-08-26
publication date: 2025-08-26
starting page: 19
ending page: 25
doi: 10.61784/jpmr3040

EARLY VERSUS DELAYED INTERVENTIONAL EMBOLIZATION FOR RUPTURED ANTERIOR COMMUNICATING ARTERY ANEURYSMS: A SINGLE-CENTER RETROSPECTIVE COHORT STUDY OF 22 CASES WITH LITERATURE REVIEW
type: item
description: Objective: To explore the clinical efficacy and safety of early interventional embolization in the treatment of ruptured anterior communicating artery aneurysms. Given the current controversy regarding the timing of interventional embolization, this study aims to provide a basis for optimizing treatment strategies. Methods: A retrospective analysis was conducted on 22 patients with ruptured anterior communicating artery aneurysms admitted to the interventional center of a hospital from January 2024 to February 2024. Patients were divided into the experimental group (interventional embolization within 72 hours of onset, n=11) and the control group (interventional embolization after 72 hours of onset, n=11) based on the timing of treatment. Data were collected on surgical success rate, complications, and neurological prognosis. Statistical analysis was performed using χ2 test and t-test. Results: The surgical success rate in the experimental group (100%) was significantly higher than in the control group (81.8%, P < 0.05). The incidence of severe complications such as severe pneumonia and hydrocephalus in the experimental group (9.1%) was significantly lower than in the control group (36.4%, P < 0.05). The mRS score at 6-month follow-up in the experimental group (1.42 ± 0.9) was better than that in the control group (2.15 ± 1.8, P < 0.05); the proportion of patients with mRS score ≤ 2 at 6-month follow-up in the experimental group (90.9%) was higher than that in the control group (72.7%, P < 0.05). These findings are consistent with previous studies that have shown early interventional embolization can significantly improve the surgical success rate, reduce the risk of complications, and improve the neurological prognosis of patients with ruptured anterior communicating artery aneurysms.Conclusion: Early interventional embolization in the treatment of ruptured anterior communicating artery aneurysms can significantly improve the surgical success rate, reduce the risk …
subject: Research Article
  topic: section
subject: Anterior communicating artery aneurysm
  topic: keywords
subject: Interventional embolization
  topic: keywords
subject: Early treatment
  topic: keywords
subject: Treatment outcome
  topic: keywords
subject: Single-center study
  topic: keywords
creator: ZhanLiang Wei
creator: JianRong Huang
creator: Jie Bin
creator: Feng Lai
rights: Copyright (c) 2025 ZhanLiang Wei; JianRong Huang; Jie Bin; Feng Lai https://creativecommons.org/licenses/by/4.0
date: 2025-08-04
publication date: 2025-08-04
starting page: 14
ending page: 18
doi: 10.61784/jpmr3039

EFFECT OF NPC1 AS AN INDEPENDENT RISK FACTOR ON THE PROGNOSIS OF CERVICAL CANCER
type: item
description: Objective: Intracellular cholesterol transporter 1 (NPC1) plays an indispensable role in the pathological process of malignant tumor. But the value of NPC1 as a biomarker in cervical cancer has not yet been revealed. Methods: 191 cervical cancer samples with NPC1 expression data and relevant clinical characteristic information were obtained from the Cancer Genome Atlas (TCGA). A series of bioinformatics analysis methods were performed to explore the biological role of NPC1 in cervical cancer. Results: Firstly, Cox regression and the Kaplan–Meier method showed that the increased expression of NPC1 was related to the decrease of overall survival time in cervical cancer. Secondly, GO enrichment analysis disclosed that some essential physiological processes were significantly correlated with NPC1 over-expression. Thirdly, KEGG enrichment analysis indicated that cancer-related signaling pathways were correlated with NPC1 expression. Fourthly, I found the close relationship between NPC1 expression and tumor immune micro-environment of cervical cancer. Finally, four small molecule drugs with potential inhibitory effect on NPC1 expression were screened by C-Map analysis. Conclusion: The high expression of NPC1 was an independent risk factor for the poor prognosis of cervical cancer. Moreover, NPC1 might be promising biomarker for the diagnosis and treatment of cervical cancer.
subject: Research Article
  topic: section
subject: Cervical cancer
  topic: keywords
subject: NPC1
  topic: keywords
subject: Poor prognosis
  topic: keywords
subject: Biomarker
  topic: keywords
subject: Bioinformatics analysis
  topic: keywords
creator: ZheYu Luan
rights: Copyright (c) 2025 ZheYu Luan https://creativecommons.org/licenses/by/4.0
date: 2025-08-01
publication date: 2025-08-01
starting page: 5
ending page: 13
doi: 10.61784/jpmr3038

ANALYSIS OF PRESCRIPTION PATTERNS OF TRADITIONAL CHINESE MEDICINE FORMULAS FOR STROKE TREATMENT
type: item
description: Stroke is a leading cause of death and disability worldwide. Despite the extensive use of traditional Chinese medicine (TCM) formulas in stroke treatment, systematic analyses of their multi-drug synergy and compatibility patterns remain scarce. This study leverages knowledge graph technology to integrate multi-source TCM formula data and constructs a knowledge graph for stroke-related TCM prescriptions. By combining frequency analysis, cluster analysis, and association rule mining, the study systematically uncovers medication patterns. A total of 1,403 validated formulas were included, identifying nine high-frequency herbs (frequency ≥ 200), such as Saposhnikoviae Radix and Glycyrrhizae Radix. These were categorized into four synergistic clusters. Five strong association rules were identified (e.g., “Ligustici Rhizoma and Almond → Ephedrae Herba” and “Scutellaria Baicalensis and Saposhnikoviae Radix → Glycyrrhizae Radix”). The utility of the knowledge graph in multidimensional retrieval and intelligent reasoning was validated. This study provides data support and a methodological paradigm for the standardized application and modernization of TCM in stroke treatment.
subject: Research Article
  topic: section
subject: Knowledge graph
  topic: keywords
subject: Traditional Chinese medicine formulas
  topic: keywords
subject: Prescription pattern
  topic: keywords
subject: Stroke
  topic: keywords
creator: XiaoMiao Gui
creator: XinQi Hu
creator: KeFan Yuan
creator: RuiNa Wang
rights: Copyright (c) 2025 XiaoMiao Gui; XinQi Hu; KeFan Yuan; RuiNa Wang https://creativecommons.org/licenses/by/4.0
date: 2025-07-15
publication date: 2025-07-15
starting page: 1
ending page: 4
doi: 10.61784/jpmr3037

ANALYSIS OF THE EFFECT OF ARTIFICIAL INTELLIGENCE-ASSISTED MINIMALLY INVASIVE TREATMENT FOR URINARY CALCULI
type: item
description: Urinary calculi, a prevalent urinary system disorder, significantly impairs patients’ quality of life and exhibits an escalating incidence. While minimally invasive surgery offers clinical advantages, it is challenged by complications, high costs, and inconsistent standards. This study explores the role of artificial intelligence (AI) in enhancing minimally invasive treatment for urinary calculi, addressing unmet needs in precision and efficacy.Using a systematic analysis, the research examines AI applications across the treatment continuum: preoperatively, AI predicts stone composition, evaluates size/location, and optimizes surgical strategies through data-driven models; intraoperatively, it enhances procedural safety and outcomes via real-time decision support; postoperatively, AI aids risk assessment for recurrence and guides personalized follow-up to reduce complications. Findings reveal that AI integration improves treatment customization and precision by synthesizing multi-dimensional clinical data, yet challenges persist, including model accuracy limitations, standardization gaps, variable physician proficiency, and economic barriers.Innovatively, this study highlights AI’s potential to transform holistic management of urinary calculi while identifying critical implementation hurdles. It underscores the need for technological refinement, standardized protocols, clinician training, and cost-containment measures to facilitate widespread adoption. By bridging AI capabilities with clinical practice, this analysis provides a practical framework for advancing minimally invasive therapies, ultimately aiming to enhance patient care through evidence-based, AI-driven solutions.
subject: Research Article
  topic: section
subject: Urinary calculi
  topic: keywords
subject: Minimally invasive surgery
  topic: keywords
subject: Artificial intelligence
  topic: keywords
subject: Assisted treatment
  topic: keywords
creator: LinFeng Li
rights: Copyright (c) 2025 LinFeng Li https://creativecommons.org/licenses/by/4.0
date: 2025-06-06
publication date: 2025-06-06
starting page: 71
ending page: 77
doi: 10.61784/jpmr3036

ESTABLISHMENT OF A METHOD FOR MONITORING MEROPENEM CONCENTRATIONS IN PATIENTS WITH SEVERE ACUTE PANCREATITIS
type: item
description: Objective: To establish a population pharmacokinetic (PPK) model for meropenem in patients with severe acute pancreatitis (SAP), providing a valuable basis and method for developing individualized meropenem dosing regimens tailored to the pathophysiological state of SAP patients; Methods: Meropenem concentrations in plasma and abdominal drainage fluid were monitored using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and homogeneous enzyme immunoassay. Nonlinear mixed-effects modeling was performed using Phoenix software; Results: (1) Meropenem concentration determination: A total of 20 SAP patients were enrolled, providing 99 qualified plasma samples and 42 qualified abdominal drainage fluid samples. Meropenem and the internal standard (metformin) were well separated in both plasma and drainage fluid samples, demonstrating good specificity. Meropenem showed excellent linearity within the ranges of 0.5 - 200 μg/mL in plasma and 0.1 - 10 μg/mL in drainage fluid. All methodological validation results fell within acceptable limits, with RSD ≤ 15%; Conclusion: This study established an LC-MS/MS method (referenced and quality-controlled by homogeneous enzyme immunoassay) for determining meropenem concentrations. The validated method is suitable for clinical therapeutic drug monitoring (TDM) of meropenem, particularly in critically ill ICU patients.
subject: Research Article
  topic: section
subject: Meropenem
  topic: keywords
subject: Severe acute pancreatitis
  topic: keywords
subject: Therapeutic drug monitoring
  topic: keywords
subject: Monte Carlo simulation
  topic: keywords
subject: Pharmacokinetics/Pharmacodynamics
  topic: keywords
subject: Individualized therapy
  topic: keywords
creator: Min Luo
creator: Wei Bu
creator: Lu Yao
creator: Liu Shi
creator: HongBo Xu
creator: WenMei Liang
creator: Yan Chen
creator: Tao Chen
creator: Bao Fu
creator: Lei Gong
rights: Copyright (c) 2025 Min Luo; Wei Bu; Lu Yao; Liu Shi; HongBo Xu; WenMei Liang; Yan Chen; Tao Chen; Bao Fu; Lei Gong https://creativecommons.org/licenses/by/4.0
date: 2025-08-30
publication date: 2025-08-30
starting page: 31
ending page: 36
doi: 10.61784/jpmr3042

MICRO-ADJUSTMENT MANIPULATION COMBINED WITH TRADITIONAL MANIPULATION FOR KNEE OSTEOARTHRITIS WITH VARUS DEFORMITY
type: item
description: Objective: To observe the effect of micro-adjustment manipulation combined with traditional manipulation versus traditional manipulation alone in the treatment of varus knee osteoarthritis (KOA) by analyzing kinetic parameters, WOMAC scores, and clinical efficacy; and to explore the mechanism of adding micro-adjustment manipulation to traditional manipulation in the treatment of KOA. Methods: A total of 80 patients with varus knee osteoarthritis (7 cases dropped out during the process) were randomly divided into two groups. The combined group (n=37) received micro-adjustment manipulation during the first knee joint treatment, followed by traditional manipulations such as “One-Finger Meditation” and “Tui Fa.” The traditional group (n=36) received only traditional manipulations such as “One-Finger Meditation” and “Tui Fa.” Both groups were treated for 4 weeks, twice a week, one course of treatment lasting 4 weeks. WOMAC scores, kinetic parameters, and clinical efficacy were observed. Results:Osteoarthritis scales: After the first manipulation and after 4 weeks of manipulation, WOMAC scores, functional scores, and VAS scores in both groups were significantly lower than before treatment (P<0.05). After the first manipulation, the pain score in the micro-adjustment group decreased more significantly than that in the traditional group (P<0.05). After 4 weeks of treatment, the stiffness score in the combined group decreased significantly compared with before treatment (P<0.05). Kinetic parameters: After 4 weeks of manipulation, the flexion torque in both groups increased compared with before treatment (P<0.05). After the first manipulation, the adduction moment impulse in the combined group decreased significantly compared with before treatment (P<0.05). Clinical efficacy: The effective rates of the combined group after the first manipulation and after 4 weeks were 83.78% and 91.89%, respectively; while those of the traditional group were 80.56% and 91.67%, with no statist…
subject: Research Article
  topic: section
subject: Varus knee osteoarthritis
  topic: keywords
subject: Micro-adjustment manipulation
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subject: One-finger meditation
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subject: Tui Fa
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subject: Kinetic parameters
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creator: KaiLong Sun
creator: ShangJun Xia
creator: Jian Zhang
rights: Copyright (c) 2025 KaiLong Sun; ShangJun Xia; Jian Zhang https://creativecommons.org/licenses/by/4.0
date: 2025-10-13
publication date: 2025-10-13
starting page: 44
ending page: 51
doi: 10.61784/jpmr3045