World Journal of Clinical Sciences
type: channel
description: World Journal of Clinical Sciences (WJCS) is an international peer-reviewed, open access journal.
publisher: UPub Science
language: en
publication name: World Journal of Clinical Sciences
issn: 2960-0278
items: EPIDEMIOLOGICAL CHARACTERISTICS AND RECENT ADVANCES IN CLINICAL MANAGEMENT OF NON-SMALL CELL LUNG CANCER
items: PERSPECTIVE OF BASAL CELL CARCINOMA : A REVIEW
items: OVERCOMING OPERATIONAL CHALLENGES: AN ANALYSIS OF CLINIC PERFORMANCE AND PATIENT TRUST IN NIGERIA’S HEALTHCARE SECTOR
items: DEVELOPING PREDICTIVE MODELS AND INTERVENTIONS TO MITIGATE THE RISKS ASSOCIATED WITH INCONSISTENT ARV USE AND IMPROVE TREATMENT OUTCOMES
items: EVALUATION OF SOME HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN PATIENTS INFECTED WITH HELICOBACTER PYLORI ATTENDING IMO STATE SPECIALIST HOSPITAL, OWERRI
items: INFLUENCE OF HEALTH EDUCATION ON PHYSICAL EXERCISE IN ALLEVIATING LOW BACK PAIN AMONG PATIENTS IN RIVERS STATE, NIGERIA
items: AGE-RELATED PATTERNS OF CHILDHOOD INJURIES IN PORT HARCOURT METROPOLIS HOSPITALS: A COMPARATIVE STUDY ACROSS FOUR AGE GROUPS
items: CHALLENGES TO OPTIMAL MIDWIFERY: PERSPECTIVES ON STAFFING AND DEVELOPMENT IN RIVERS STATE PRIMARY HEALTH CARE CENTRES
items: HBV RNA AS A PREDICTOR OF HBEAG SEROCONVERSION IN PATIENTS WITH HEPATITIS B
items: CHRYSOPHYLLUM ALBIDUM STEM BARK POWDER: EFFECTS ON GROWTH PERFORMANCE AND CARCASS CHARACTERISTICS OF JAPANESE QUAILS (COTURNIX JAPONICA)
items: STATUS OF ERYTHROCYTE SEDIMENTATION RATE, RED CELL AND PLATELET INDICES IN PATIENTS WITH CHRONIC KIDNEY DISEASE IN OWERRI METROPOLIS, NIGERIA
items: RECENT DEVELOPMENTS IN THE MANAGEMENT AND THERAPY OF WOUNDS EXHIBITING COMPLEX PRESENTATIONS
items: AN IN-DEPTH STUDY OF THE DIAGNOSTIC UTILITY OF MAGNETIC RESONANCE DIFFUSION-WEIGHTED IMAGING IN THE IDENTIFICATION OF EARLY-STAGE LIVER CANCER
items: UTILITY OF CIRCULATING TUMOR CELLS IN ENHANCING THE THERAPEUTIC STRATEGIES FOR NON-SMALL CELL LUNG CANCER
items: RESEARCH AND APPLICATION OF LABORATORY MEDICINE REFERENCE MEASUREMENT SYSTEM
items: ADVANCES IN ADOPTIVE CELLULAR IMMUNOTHERAPY IN MULTIPLE MYELOMA
items: THE ROLE OF MICRORNA-186 IN UROGENITAL TUMORS
items: STUDY ON INFLUENCING FACTORS OF BIOCHEMICAL TESTS
items: CLINICAL APPLICATION AND RISK MANAGEMENT OF INFUSION PUMPS
items: EARLY DIAGNOSIS AND CLINICAL ANALYSIS OF TYPE Ⅲ CONGENITAL ESOPHAGEAL ATRESIA COMPLICATED WITH TRACHEOMALACIA
items: RESEARCH PROGRESS ON THE PATHOGENESIS AND CLINICAL MANIFESTATIONS OF COVID -19
items: PROGRESS IN PHYSICAL THERAPY FOR DRY EYE DISEASE
items: REFLUX IN THE ELDERLY ESOPHAGUS CLINICAL INFLAMMATION RESEARCH STUDY ENTER EXHIBITION
items: RESEARCH PROGRESS ON BREAST RECONSTRUCTION IN PATIENTS WITH BREAST CANCER
items: RESEARCH PROGRESS ON CLINICAL APPLICATION AND SAFETY MANAGEMENT OF TOPIRAMATE

EPIDEMIOLOGICAL CHARACTERISTICS AND RECENT ADVANCES IN CLINICAL MANAGEMENT OF NON-SMALL CELL LUNG CANCER
type: item
description: Non-small cell lung cancer (NSCLC) constitutes 80%-85% of all lung cancer cases. Epidemiological data reveal global variations in incidence, with rates increasing with age, higher prevalence in males, and a shift from squamous cell carcinoma to adenocarcinoma as the dominant subtype. Although the 5-year survival rate remains low, prognosis has shown gradual improvement. Advances in diagnostic technologies, including PET-CT and video-assisted biopsy techniques, have enhanced diagnostic precision. Current treatment strategies prioritize surgery-based multimodal regimens, complemented by personalized approaches. Targeted therapies and immunotherapies now offer novel therapeutic avenues for NSCLC patients.
subject: Research Article
  topic: section
subject: Non-small cell lung cancer
  topic: keywords
subject: Epidemiology
  topic: keywords
subject: Clinical diagnosis and treatment
  topic: keywords
subject: Therapeutic innovations
  topic: keywords
creator: ChongQi Fan
creator: HuanWen Chen
rights: Copyright (c) 2025 ChongQi Fan; HuanWen Chen https://creativecommons.org/licenses/by/4.0
date: 2025-03-24
publication date: 2025-03-24
starting page: 11
ending page: 15
doi: 10.61784/wjcs3019

PERSPECTIVE OF BASAL CELL CARCINOMA : A REVIEW
type: item
description: The most common cause of Basal Cell Carcinoma (BCC) is DNA damage brought on by exposure to ultraviolet (UV) radiation from the sun or indoor tanning, which alters the basal cells of the epidermis, the skin's outermost layer and causes unchecked growth.Open sores, red patches, pink growths, shiny bumps, scars, or growths with a central indentation and/or slightly elevated, rolled edges are all possible appearances for BCCs. At times, BCCs may ooze, crust, itch or bleed. Usually, the lesions appear in parts of the body that are exposed to the sun.About half of BCCs in patients with darker skin are pigmented, which means they are tan, black, or brown in color and could be confused with a typical mole. It's crucial to remember that various people may have very varied BCCs.
subject: Research Article
  topic: section
subject: Basal cell carcinoma
  topic: keywords
subject: Perspective
  topic: keywords
subject: A review
  topic: keywords
creator: Olaleye Wasiu Babatunde
creator: Nnodim Johnkennedy
rights: Copyright (c) 2025 Olaleye Wasiu Babatunde; Nnodim Johnkennedy https://creativecommons.org/licenses/by/4.0
date: 2025-02-22
publication date: 2025-02-22
starting page: 7
ending page: 10
doi: 10.61784/wjcs3016

OVERCOMING OPERATIONAL CHALLENGES: AN ANALYSIS OF CLINIC PERFORMANCE AND PATIENT TRUST IN NIGERIA’S HEALTHCARE SECTOR
type: item
description: This research article investigates the critical challenges faced by clinics in Nigeria, focusing on their failure to maintain operational standards and uphold their reputation in the healthcare sector. The primary objective of the study is to identify the underlying factors contributing to the decline in service quality and patient trust in these healthcare facilities. To achieve this, a mixed-methods approach was employed. Quantitative data were collected through surveys administered to patients and healthcare workers in various clinics across Nigeria. This was complemented by qualitative interviews with clinic administrators and regulatory bodies. The data were analyzed to identify patterns in service delivery, patient satisfaction, and operational practices. The findings reveal that many clinics struggle with inadequate resources, poor management practices, and a lack of adherence to established health guidelines. Common issues include insufficient staff training, outdated medical equipment, and financial constraints that hinder the acquisition of necessary supplies. Additionally, the study highlights systemic problems such as corruption and a lack of effective regulatory oversight, which exacerbate the challenges faced by these clinics. The implications of these findings are significant. They suggest that urgent reforms are needed to enhance the operational capacity of clinics in Nigeria. This includes improving training programs for healthcare providers, ensuring better regulatory compliance, and fostering a culture of accountability within the healthcare system. By addressing these issues, clinics can work towards restoring their reputation and providing higher-quality care to patients, ultimately contributing to a healthier population in Nigeria.
subject: Research Article
  topic: section
subject: Clinics
  topic: keywords
subject: Patients
  topic: keywords
subject: Population
  topic: keywords
subject: Health
  topic: keywords
subject: Education
  topic: keywords
creator: Okechukwu Chidoluo Vitus
rights: Copyright (c) 2025 Okechukwu Chidoluo Vitus https://creativecommons.org/licenses/by/4.0
date: 2025-01-10
publication date: 2025-01-10
starting page: 1
ending page: 6
doi: 10.61784/wjcs3011

DEVELOPING PREDICTIVE MODELS AND INTERVENTIONS TO MITIGATE THE RISKS ASSOCIATED WITH INCONSISTENT ARV USE AND IMPROVE TREATMENT OUTCOMES
type: item
description: Antiretroviral drugs (ARVs) are the mainstay of HIV infection management. They are essential not only to suppress the viral load, but also to improve the quality of life of people living with HIV. Consistent adherence to prescribed ARV treatments is essential to achieve viral suppression, reduce the risk of drug resistance and ensure long-term health benefits. However, non-adherence to ARV treatment remains a persistent and complex problem that poses significant risks to treatment effectiveness and complicates HIV care. Irregular adherence to treatment can lead to treatment failure, the development of drug-resistant viral strains, and the rapid deterioration of the patient's overall health. These challenges are exacerbated by various factors, including socioeconomic barriers, psychological stress, side effects, lack of health infrastructure, and behavioral problems that affect patients' willingness or ability to adhere to prescribed treatments. This study aims to address the problem of inconsistent ARV use by developing predictive models to better understand the factors that contribute to non-adherence and to design effective and targeted interventions that can mitigate the risks associated with missed doses. To achieve this, the research will analyze a comprehensive set of patient data, integrating demographic information (such as age, sex, and socioeconomic status), clinical data (including health conditions, CD4 count, and viral load), and behavioral variables (such as mental health status, substance abuse, and social support systems). The goal is to identify specific predictors that contribute to poor adherence, ranging from individual patient characteristics to broader systemic factors. Integrating advanced machine learning techniques, this study will generate predictive models that can predict adherence behaviors, allowing healthcare providers to identify patients at risk before adherence problems become severe. These models will not only predict patterns of n…
subject: Research Article
  topic: section
subject: Predictive models
  topic: keywords
subject: Interventions
  topic: keywords
subject: Inconsistent ARV use & treatment outcomes
  topic: keywords
creator: Joshua HK. Banda
rights: Copyright (c) 2024 Joshua HK. Banda https://creativecommons.org/licenses/by/4.0
date: 2024-12-30
publication date: 2024-12-30
starting page: 6
ending page: 15
doi: 10.61784/wjcs3014

EVALUATION OF SOME HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN PATIENTS INFECTED WITH HELICOBACTER PYLORI ATTENDING IMO STATE SPECIALIST HOSPITAL, OWERRI
type: item
description: Helicobacter pylori is a bacterium that causes peptic ulcer disease. This study was aimed at determining the levels of some haematological parameters and biochemical parameters of patients infected with Helicobacter pylori attending Imo State Specialist, Hospital Umuguma, Owerri. A cross-sectional study was carried out from the month of June to August, 2023 and all eligible subjects who filled the questionnaire and gave a written informed consent for the study were sampled. The study population consisted of 50 H. pylori infected patients and an equivalent number of aged - matched healthy subjects, who served as the controls. Blood samples were collected from the participants and analysed for PCV using micro haematocrit method, Red blood cell counts using Thoma (manual counting) method, serum iron (Ferrozine method) and amylase using enzymatic method. The results of the tests were analyzed using SPSS version 21.The mean values of PCV (31.36±3.53)%, RBC (3.93±4.69)x1012/L and serum iron (48.22±19.66)μg/dl were significantly reduced in H. pylori infected individual when compared to controls (36.10±3.37)%, (5.25±7.13)x1012/L and (79.16±19.32), μg/dl (p=0.000). The mean value of amylase (95.15±34.88) U/L was significantly increased in H. pylori infected individuals when compared to controls (52.92±11.44) U/L. There was no significant difference in the mean values of PCV (32.29±3.49)%, RBC (3.76±3.71) x109/L, Iron (45.18±17.59) μg/dl and Amylase (99.28±37.86)U/L in male H. pylori infected individuals when compared to the females. (30.50±3.40)%, (4.08±5.51) x109/L, (51.04±21.35) μg/dl and (91.35±32.15) U/L t=1.83, (p=0.073, t=1.06, p=0.297, t=0.80, p=0.427, t= 0.23, and p=0.818. H.pylori infection leads to a decline in packed cell volume, RBC and serum iron levels and an increase in amylase. Gender difference does not have an effect on PCV, RBC, iron and amylase levels in H. Pylori infection.
subject: Research Article
  topic: section
subject: Peptic ulcer
  topic: keywords
subject: Helicobacter pylori
  topic: keywords
subject: Packed cell volume
  topic: keywords
subject: Red blood cell
  topic: keywords
subject: Amylase
  topic: keywords
subject: Serum Iron
  topic: keywords
creator: Aloy-Amadi Oluchi C.
creator: Ogboso Sophy C.
creator: Eberendu I.F.
creator: Ukonu Uche C.
creator: Emeka-Obi Obioma R.
creator: Nwabueze Jennifer U.
rights: Copyright (c) 2024 Aloy-Amadi Oluchi C.; Ogboso Sophy C.; Eberendu I.F.; Ukonu Uche C.; Emeka-Obi Obioma R.; Nwabueze Jennifer U. https://creativecommons.org/licenses/by/4.0
date: 2024-12-19
publication date: 2024-12-19
starting page: 1
ending page: 5
doi: 10.61784/wjcs3009

INFLUENCE OF HEALTH EDUCATION ON PHYSICAL EXERCISE IN ALLEVIATING LOW BACK PAIN AMONG PATIENTS IN RIVERS STATE, NIGERIA
type: item
description: This study investigated the influence of health education on physical exercise in alleviating low back pain among patients in Rivers State, Nigeria. The study utilized a pretest-posttest quasi-experimental design and involved 170 patients at the University of Port Harcourt Teaching Hospital. Two objectives were set, along with corresponding research questions and hypotheses. The participants were selected using convenience and stratified sampling techniques, resulting in a cohort of 50 individuals consisting of 35 patients from the general outpatient clinic department and 15 patients from the spine physiotherapy unit. The group included 20 male and 30 female participants. Data was collected using a self-structured, self-administered questionnaire titled physical exercise-focused health education in alleviating low back pain, which demonstrated good reliability (0.82). Descriptive and inferential statistics were employed to analyze the data and test the hypotheses. The study findings indicated that health education, with a focus on physical exercise (PEFHE) for low back pain patients, consistently improved mobility by enhancing respiration, reducing abdominal fat, strengthening muscles and increasing flexibility. More so, PEFHE significantly alleviated pain and stiffness among individuals with low back pain. In conclusion, the study recommends the implementation of comprehensive PEFHE programmes, fostering patient participation, conducting further research on long-term effects, and promoting collaboration among healthcare providers, educators, and policymakers to integrate these interventions into the existing healthcare system seamlessly.
subject: Research Article
  topic: section
subject: Physical exercise-focused health education
  topic: keywords
subject: PEFHE
  topic: keywords
subject: Low back pain patients
  topic: keywords
creator: Ime M. Ubom
creator: Richard C. Echem
creator: Anelechi K. Madume
creator: Golda O. Ekenedo
rights: Copyright (c) 2024 Ime M. Ubom; Richard C. Echem; Anelechi K. Madume; Golda O. Ekenedo https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 15
ending page: 22
doi: 10.61784/wjcs3003

AGE-RELATED PATTERNS OF CHILDHOOD INJURIES IN PORT HARCOURT METROPOLIS HOSPITALS: A COMPARATIVE STUDY ACROSS FOUR AGE GROUPS
type: item
description: This comparative study analyzed age-related childhood injury patterns across four age groups in selected model primary healthcare centers in Port Harcourt metropolis (mPHCs). The research design was a descriptive study. The study population comprised 50 pediatric nurses from the mPHCs. Census sampling selected all eligible nurses. A self-structured instrument, age-related childhood injury patterns questionnaire, elicited data on injury trends. Expert review and pilot testing ensured validity and a Cronbach's alpha of 0.75 confirmed reliability. Data collection involved self-administered 50 copies of questionnaire distributed to participants. Descriptive statistics addressed the research questions on injury types and prevalence per age group. Inferential statistics using Chi-square and Likelihood ratio analyzed variable associations and tested hypotheses on age-injury associations. Key findings showed distinctive injury profiles for infants, toddlers, young children, and adolescents, indicating age as a major determinant of childhood injury patterns. Bruises, minor burns and ingestions predominated among infants and toddlers while cuts, fractures, and sprains were more prevalent in older groups. Injury prevalence per age revealed 1-5 years as the highest risk group. Inferential statistics confirmed significant associations between age and injuries like ingestion, sprains, and fractures. The study concluded that recognizing age-specific injury patterns is vital to guide targeted interventions and protocols for childhood injury prevention and management within pediatric primary care. Recommendations included developmental screening, age-appropriate parental education, and multi-sectoral collaboration to bolster child safety.
subject: Research Article
  topic: section
subject: Age-Related
  topic: keywords
subject: Childhood injury patterns
  topic: keywords
subject: Ingestion
  topic: keywords
subject: Sprains
  topic: keywords
subject: Fractures
  topic: keywords
creator: Lesi Ngozi Omemu
creator: Diuto Akani
rights: Copyright (c) 2024 Lesi Ngozi Omemu; Diuto Akani https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 23
ending page: 29
doi: 10.61784/wjcs3004

CHALLENGES TO OPTIMAL MIDWIFERY: PERSPECTIVES ON STAFFING AND DEVELOPMENT IN RIVERS STATE PRIMARY HEALTH CARE CENTRES
type: item
description: This study investigated midwives' perspectives on staffing and development challenges impacting optimal midwifery in Rivers State primary healthcare centers. It utilized a descriptive survey design with a sample of 217 midwives selected through stratified total census sampling. Data was collected via the validated 'Midwifery Staff and Development Management Challenges Questionnaire' and analyzed using means, standard deviations and z-test. Key findings showed midwives disagreed that professional barriers cause shortages but agreed recruitment and retention are critical, though perspectives differed between full-timers and clinical staff. Existing mentoring programs were deemed insufficient and increased investments needed to enhance skills and tackle practice challenges. The study concluded that despite diverging opinions on causes, midwives collectively concur that strengthening staff numbers and development opportunities is vital for optimal midwifery practice. Targeted, evidence-based workforce initiatives are recommended, but a comprehensive strategy must also address underlying motivational, infrastructural and coordination issues using systems-thinking. Suggestions include objective workload analysis, outcome assessments, service user feedback, and collaborative mechanisms between midwives, administrators and policymakers to enrich understanding and tailor interventions.
subject: Research Article
  topic: section
subject: Midwifery
  topic: keywords
subject: Staffing
  topic: keywords
subject: Development
  topic: keywords
subject: Primary care
  topic: keywords
subject: Perspectives
  topic: keywords
creator: Enyi Oronwemgbe Shedrack
creator: Ihudiebube-Splendor Chikodili
rights: Copyright (c) 2024 Enyi Oronwemgbe Shedrack; Ihudiebube-Splendor Chikodili https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 30
ending page: 36
doi: 10.61784/wjcs3005

HBV RNA AS A PREDICTOR OF HBEAG SEROCONVERSION IN PATIENTS WITH HEPATITIS B
type: item
description: Objective: To study the predictive value of serum hepatitis B virus pregenomic RNA (HBV pgRNA) in the seroconversion of HBeAg-positive chronic hepatitis B (CHB) patients. Methods: 135 patients with HBeAg positive CHB patients were admitted to our hospital from June 2021 to June 2022 were selected to detect the serum HBV pgRNA and HBV DNA levels with antiviral therapy at 12 weeks, 24 weeks, 48 weeks and 96 weeks . Receiver operating characteristic analyses was used to determine baseline and and on-treatment HBV RNA levels associated with response. Result: The serum HBV pgRNA levels at 12, 24, 48, and 96 weeks after treatment were (5.11 ± 0.76) log 10 IU/ml, (4.56 ± 0.43) log 10 IU/ml, (3.22 ± 0.36) log 10 IU/ml, and (1.54 ± 0.22) log 10 IU/ml, respectively; The levels of HBV DNA in HBeAg positive CHB patients at different stages were (5.01 ± 0.84) log 10 IU/ml, (4.73±0.52) log 10 IU/ml, (3.38 ± 0.52) log 10 IU/ml, and (1.32 ± 0.35) log 10 IU/ml, respectively. The serum HBV pgRNA and HBV DNA levels were all lower than before treatment, and the differences were statistically significant(P<0.05); significant serum conversion occurred in HBeAg positive patients at 24 weeks that HBeAg positive rate of 71.11%, HBV pgRNA positive rate of 69.63%, and HBV DNA positive rate of 36.30% after antiviral therapy. The sensitivity and specificity of serum HBV pgRNA in predicting serum HBeAg seroconversion were 89.20% and 80.95%, which were higher than those of serum HBV DNA at 67.96% and 67.92%. Conclusion: Serum HBV pgRNA and HBV DNA levels in HBeAg positive CHB patients were gradually decreased with the prolongation of antiviral treatment time. Both may serve as a certain guiding role in antiviral treatment of CHB patients, but the predictive value of HBV pgRNA is higher than HBVDNA in the seroconversion of HBeAg-positive CHB patients.
subject: Research Article
  topic: section
subject: Hepatitis B virus pregenomic RNA
  topic: keywords
subject: Hepatitis B e antigens
  topic: keywords
subject: Chronic hepatitis B
  topic: keywords
subject: Antiviral therapy
  topic: keywords
creator: Jun Tian
creator: Zheng Zhou
creator: HuaLing Tan
creator: Ke Wang
rights: Copyright (c) 2024 Jun Tian; Zheng Zhou; HuaLing Tan; Ke Wang https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 37
ending page: 40
doi: 10.61784/wjcs3006

CHRYSOPHYLLUM ALBIDUM STEM BARK POWDER: EFFECTS ON GROWTH PERFORMANCE AND CARCASS CHARACTERISTICS OF JAPANESE QUAILS (COTURNIX JAPONICA)
type: item
description: This experiment was carried out to determine the effect of Chrysophyllum albidum stem bark powder (CASB) on the growth performance and carcass characteristics of Japanese quails. A total of 300 - 2 weeks old male Japanese quails were randomly divided into 5 groups each with 60 birds. Each group was further sub-divided in to six groups each with 10 quails of comparable group weight. Regular diet was formulated to meet all the nutrient requirements for birds according to NRC (1994). Quails in group A (Ta) received regular diet without CASB while those in Tb, Tc, Td and Te were fed same diet supplemented with CASB at 100 g, 200 g, 300 g and 400 g per kg respectively. A completely randomized design was adopted and birds had unrestricted access to fresh clean water and feed throughout the 30 days experimental period. Qualitative assessment of CASB reveals the presence of tannins, phenols, saponins, alkaloids, flavonoids, tannins and terpenoids was observed in CASB. Average daily weight gain, average daily feed intake, feed conversion ratio and mortality were significantly (P<0.05) influenced by the treatment. Quails fed diet supplemented with CASB recorded a higher (P<0.05) average body weight and average daily feed intake relative to Ta (control), increasing the levels of CASB significantly reduced (P<0.05) feed conversion ratio and mortality. Carcass weight, dressing percentage and weights of breast, thigh, drumstick, wing and back were higher in Tc, Td and Te, intermediate in Tb and lower in Ta (P<0.05) while weight of head, neck and shank were not affected by the treatment (P>0.05). CASB can be supplemented up to 400g/kg in the diet of quails without affecting the performance of birds.
subject: Research Article
  topic: section
subject: Chrysophyllum albidum
  topic: keywords
subject: Growth
  topic: keywords
subject: Performance
  topic: keywords
subject: Phytochemicals
  topic: keywords
subject: Quails
  topic: keywords
creator: Olujimi
creator: Alagbe John
creator: Anuore
creator: DN
creator: Aliyu
creator: KI
rights: Copyright (c) 2024 Olujimi; Alagbe John; Anuore; DN; Aliyu; KI https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 41
ending page: 48
doi: 10.61784/wjcs3007

STATUS OF ERYTHROCYTE SEDIMENTATION RATE, RED CELL AND PLATELET INDICES IN PATIENTS WITH CHRONIC KIDNEY DISEASE IN OWERRI METROPOLIS, NIGERIA
type: item
description: Kidney disease is a condition where the kidneys are damaged and unable to function properly. This study was aimed at investigating the status of erythrocyte sedimentation rate, red cell and platelet indices in patients with chronic kidney disease in Owerri metropolis. A total of fifty (50) subjects who were 18 years and above were recruited for the study. Twenty five (25) patients with chronic kidney disease and twenty five (25) age-matched apparently healthy individuals (controls). Samples were collected aseptically, and prepared by standard methods prior to use. Estimation of Erythrocyte Sedimentation Rate (ESR) was done using Westergren method. Estimations of red cell and platelet indices were done using Bio Maxima BM HEM 3 automated hematology analyzer. This study showed that the mean value of ESR was significantly increased in patients with chronic kidney disease when compared to the healthy controls, while the mean values of MCV, MCH, MCHC, MPV, PCT and PDW were significantly reduced in patients with chronic kidney disease when compared to healthy controls (p=0.000 and 0.015). There was no significant difference in the mean values of RDW and PLT in patients with chronic kidney disease when compared to the healthy controls (p=0.857 and p=0.552). There was no significant difference in the mean values of ESR, MCV, MCH, MCHC, RDW, PLT, MPV, PCT and PDW in male patients suffering from kidney disease when compared to females (p=0.538, p=0.460, p=0.315, p=0.183, p=0.477, p=0.085, p=0.824, p=0.089 and p=0.230). The result clearly indicates that an increase in ESR correlates with a decrease in MCV and PDW. Kidney disease is associated with a significant increase in ESR and a decrease in MCV, MCH, MCHC, MPV and PCT.
subject: Research Article
  topic: section
subject: Red blood cell
  topic: keywords
subject: Erythrocyte sedimentation rate
  topic: keywords
subject: Chronic kidney disease
  topic: keywords
subject: Red blood cell indices
  topic: keywords
subject: Platelet indices
  topic: keywords
creator: Aloy-Amadi Oluchi C.
creator: Oguegbu Victor I.
creator: Emeka-Obi Obioma R.
creator: Akogu O.
creator: Ugwuegbulem Callista O.
rights: Copyright (c) 2024 Aloy-Amadi Oluchi C.; Oguegbu Victor I.; Emeka-Obi Obioma R.; Akogu O.; Ugwuegbulem Callista O. https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 49
ending page: 53
doi: 10.61784/wjcs3008

RECENT DEVELOPMENTS IN THE MANAGEMENT AND THERAPY OF WOUNDS EXHIBITING COMPLEX PRESENTATIONS
type: item
description: Wound problem is a medical problem faced by surgeons, and the treatment of problematic wounds is a complex medical practice. With the development of medical technology, various methods are also used in clinical practice to prevent the occurrence of problem wounds and promote the healing of problem wounds. Through literature review, this article summarizes the current status and progress of the definition of problem wounds and their prevention and treatment, so as to improve the understanding and treatment of problem wounds.
subject: Research Article
  topic: section
subject: Problem wounds
  topic: keywords
subject: Wound healing
  topic: keywords
subject: Treatment
  topic: keywords
creator: Medici Peana
rights: Copyright (c) 2024 Medici Peana https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 10
ending page: 14
doi: 10.61784/wjcsv2n234

AN IN-DEPTH STUDY OF THE DIAGNOSTIC UTILITY OF MAGNETIC RESONANCE DIFFUSION-WEIGHTED IMAGING IN THE IDENTIFICATION OF EARLY-STAGE LIVER CANCER
type: item
description: Liver cancer is one of the common malignant tumors in my country. Timely diagnosis and treatment of small liver cancer are crucial to improving patient prognosis and survival rate. In recent years, with the rapid development of MRI diffusion-weighted imaging (DWI) technology, it has been widely used in the diagnosis and treatment of abdominal diseases. Currently, the detection rate and diagnosis rate of MRI for small liver cancer are better than those of CT and ultrasound. The combined application of DWI sequence is of great significance for the diagnosis of small liver cancer. This article reviews the application value of DWI imaging technology in the clinical diagnosis of small liver cancer.
subject: Research Article
  topic: section
subject: Small liver cancer
  topic: keywords
subject: Magnetic resonance imaging
  topic: keywords
subject: Diffusion weighted imaging
  topic: keywords
subject: Apparent diffusion coefficient
  topic: keywords
creator: Cecilia Thung
rights: Copyright (c) 2024 Cecilia Thung https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 6
ending page: 9
doi: 10.61784/wjcsv2n233

UTILITY OF CIRCULATING TUMOR CELLS IN ENHANCING THE THERAPEUTIC STRATEGIES FOR NON-SMALL CELL LUNG CANCER
type: item
description: Metastasis and recurrence are regarded as core factors affecting the prognosis of malignant tumors. In the basic theoretical components of metastasis and recurrence, tumor cell groups use the circulatory system to transport to distant organs, just like seeds spread in the soil, forming metastases with characteristics similar to those of the original tumors. The metastasis theory vividly It clarified the metastasis channels of malignant tumors and pointed out that "seed" tumor cells, also known as circulating tumor cells, are the focus of tumor metastasis and recurrence, and have a reliable basis for clinical analysis. In recent years, circulating tumor cells (CTCs), as potential biomarkers of tumor biology and tumor metastasis, have aroused great enthusiasm among oncologists and have become a hot topic in tumor biology analysis. This article reviews the clinical value of circulating tumor cells in non-small cell lung cancer and its clinical analysis, especially the diagnosis and treatment of lung cancer.
subject: Research Article
  topic: section
subject: Non-small cell lung cancer
  topic: keywords
subject: Circulating tumor cells
  topic: keywords
subject: Liquid biopsy
  topic: keywords
creator: Joanna Byrne
rights: Copyright (c) 2024 Joanna Byrne https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 1
ending page: 5
doi: 10.61784/wjcsv2n232

RESEARCH AND APPLICATION OF LABORATORY MEDICINE REFERENCE MEASUREMENT SYSTEM
type: item
description: The construction of laboratory medicine reference measurement system is an important guarantee for the traceability of medical laboratory test results, and is also an important basis for achieving standardization and mutual recognition of results. Over the past half century, a laboratory medicine reference measurement system structured around reference measurement procedures, reference materials and reference measurement laboratories has been basically formed and gradually improved. In the past 10 years, the development of China's medical reference measurement laboratories has made significant progress, but the research on reference measurement procedures and reference materials lags behind. The six papers published in the special topic "Research and Application of Reference Measurement Systems in Laboratory Medicine" respectively deal with standardization of clinical chemistry, establishment of reference measurement procedures and uncertainty assessment, development of reference materials and evaluation of matrix effects, and the application of reference measurement systems in in vitro diagnosis. Products (IVD) and applications in laboratory quality evaluation are introduced, hoping to provide reference for further promoting the research and application of Chinese medical reference measurement systems.
subject: Research Article
  topic: section
subject: Measurement system
  topic: keywords
subject: Measurement procedure
  topic: keywords
subject: Material
  topic: keywords
subject: Measurement laboratory
  topic: keywords
creator: Alan Ninad
rights: Copyright (c) 2024 Alan Ninad https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 12
ending page: 15
doi: 10.61784/wjcs240156

ADVANCES IN ADOPTIVE CELLULAR IMMUNOTHERAPY IN MULTIPLE MYELOMA
type: item
description: Multiple myeloma (MM) is a malignant plasma cell tumor that is still an incurable disease. In recent years, adoptive cell therapy (ACT) has developed rapidly in hematological tumors. This article mainly reviews the application progress from bone marrow infiltrating lymphocytes to genetically modified T cells to NK cells in MM. In general, ACT therapy for multiple myeloma is gradually developing towards high specificity and strong lethality. However, finding specific target antigens and preventing toxic effects of treatment are still two major problems for ACT.
subject: Research Article
  topic: section
subject: Hematology
  topic: keywords
subject: Multiple myeloma
  topic: keywords
subject: Adoptive cell therapy
  topic: keywords
subject: Bone marrow infiltrating lymphocytes
  topic: keywords
subject: CAR-T cells
  topic: keywords
subject: TCR-T cells
  topic: keywords
subject: CAT-NK cells
  topic: keywords
creator: Rhian Bakker
rights: Copyright (c) 2024 Rhian Bakker https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 8
ending page: 11
doi: 10.61784/wjcs240155

THE ROLE OF MICRORNA-186 IN UROGENITAL TUMORS
type: item
description: MicroRNA (miR) is involved in carcinogenesis and the development of human cancers. A large number of studies have been conducted on the expression of miR-186 in various cancers, including genitourinary system tumors. The results show that miR-186 affects various aspects of tumors. This biological process can be used as a marker for the diagnosis and prognosis assessment of genitourinary system tumors. This article reviews the research progress of miR-186 in urogenital tumors.
subject: Research Article
  topic: section
subject: Genitourinary system tumors
  topic: keywords
subject: MICRORNA-186
  topic: keywords
subject: Tumor biology
  topic: keywords
creator: Karla Andrea
rights: Copyright (c) 2024 Karla Andrea https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 4
ending page: 7
doi: 10.61784/wjcs240154

STUDY ON INFLUENCING FACTORS OF BIOCHEMICAL TESTS
type: item
description: Biochemical tests can accurately reflect the patient’s current physical condition. Clinical diagnosis and treatment options for many diseases must be completed with the help of biochemical test results. This medical testing method has a very high usage rate in hospitals and has other functions. Testing and diagnostic methods have incomparable advantages. Biochemical tests play an extremely important role in clinical diagnosis and treatment. For the diagnosis and treatment of diseases, whether the biochemical test results are accurate will have a critical impact on the diagnosis and treatment effects of the disease. If the biochemical test results are inaccurate, it will have a negative impact on the diagnosis and treatment of the disease. If the sample is contaminated during the sampling process, even if it can be collected again, it will take a lot of time and materials, and may even cause dissatisfaction among patients. Although overall, all major medical institutions in my country have a complete and strict set of quality control measures when conducting biochemical tests, it is undeniable that there are still many biochemical test quality risks. To this end, we must start from all aspects to strengthen the management of biochemical test quality and eliminate all interference factors that may adversely affect the biochemical test results. This article reviews research on factors that may affect biochemical test results.
subject: Research Article
  topic: section
subject: Biochemical tests
  topic: keywords
subject: Influencing factors
  topic: keywords
subject: Drug effects
  topic: keywords
subject: Blood routine
  topic: keywords
subject: Sample tubes
  topic: keywords
creator: Linda Neves
rights: Copyright (c) 2024 Linda Neves https://creativecommons.org/licenses/by/4.0
date: 2024-01-01
publication date: 2024-01-01
starting page: 1
ending page: 3
doi: 10.61784/wjcs240153

CLINICAL APPLICATION AND RISK MANAGEMENT OF INFUSION PUMPS
type: item
description: As one of the commonly used clinical medical instruments, the infusion pump provides convenience for clinical treatment. At the same time, there are also many risk factors that endanger the patient's condition. Therefore, this study takes infusion pumps as the object, analyzes the clinical application and risk management research progress of infusion pumps, and provides basis and reference for clinical treatment.
subject: Research Article
  topic: section
subject: Infusion pump
  topic: keywords
subject: Application risk
  topic: keywords
subject: Management strategies
  topic: keywords
subject: Medical equipment quality control
  topic: keywords
subject: Medical safety consumables matching
  topic: keywords
creator: Robison Barranday
rights: Copyright (c) 2023 Robison Barranday https://creativecommons.org/licenses/by/4.0
date: 2023-01-01
publication date: 2023-01-01
starting page: 21
ending page: 24
doi: 10.61784/wjcs231246

EARLY DIAGNOSIS AND CLINICAL ANALYSIS OF TYPE Ⅲ CONGENITAL ESOPHAGEAL ATRESIA COMPLICATED WITH TRACHEOMALACIA
type: item
description: To explore the type Ⅲ congenital esophageal atresia (c ongenital esophageal atresia, CEA) Combined tracheomalacia (tra- cheomalacia, TM) Early diagnosis method and clinical outcome, providing clinical diagnosis and treatment experience for CEA combined with TM. This article collects from November 2019 to 2020 Year In September, Guangzhou Women and Children’s Medical Center was admitted to the Neonatal Surgery Intensive Care Unit and underwent electronic bronchial surgery before operation. Clinical data of patients with type Ⅲ CEA examined by endoscopy, 15 patients who underwent electronic bronchoscopy before and after esophageal repair Airway assessment results and clinical outcomes were retrospectively analyzed. 15 male 12 Example, female 3 example; Gestational age at birth (34 ~ 40.6) weeks, the median gestational age at birth was 38.3 week; 7 Case (46.7%) Esophageal stricture present, 5 example(33.3 %) Imaging studies suggest gastroesophageal reflex stream; 14 cases (93.3%) Combined TM (2 cases were mild, 10 For moderate, 2 For example, severe), 8 Postoperative 1 monthly reassessment tm Comparing More obvious before, 3 cases were moderate TM, 5 cases were severe TM. 4 cases (26.67%) Postoperative asymptomatic; 11 example(73.33%) manifested as phlegm, choking Cough, cyanosis, shortness of breath, milk refusal, suffocation, etc. 2 cases of suffocation after eating were successfully rescued. During the follow-up period, there was no recurrence of esophagotracheal fistula. No anastomotic leak and hiatal hernia occurred. TM is a common complication of CEA and is Occurrence of respiratory tract-related symptoms after CEA surgery An important reason for the high rate, electronic bronchoscopy can diagnose and evaluate TM early to guide clinical treatment. TM can cause life-threatening In case of incidents, long-term respiratory follow-up is recommended for timely treatment.
subject: Research Article
  topic: section
subject: Esophageal atresia
  topic: keywords
subject: Esophageal Atresia
  topic: keywords
subject: Tracheomalacia
  topic: keywords
subject: Treatment outcome.
  topic: keywords
creator: Enrique Magana
creator: Shaonian Zhu
rights: Copyright (c) 2023 Enrique Magana; Shaonian Zhu https://creativecommons.org/licenses/by/4.0
date: 2023-03-15
publication date: 2023-03-15

RESEARCH PROGRESS ON THE PATHOGENESIS AND CLINICAL MANIFESTATIONS OF COVID -19
type: item
description: COVID-19 Since the outbreak in 2019, it has seriously affected global public health and is still epidemic in many countries. This review was approved by NCBI, CNKI, Web Search COVID-19 related literature in of Science, China National Knowledge Infrastructure and official reports to summarize and systematically explain the current COVID-19 genome characteristics. Research progress and existing deficiencies on the points, infection mechanism, and clinical characteristics, in order to provide new ideas and valuable reference materials for COVID -19 research and prevention and control.
subject: Research Article
  topic: section
subject: COVID-19
  topic: keywords
subject: Genome
  topic: keywords
subject: Mechanism of infection
  topic: keywords
subject: Clinical manifestations
  topic: keywords
creator: Melanie C. Alden
rights: Copyright (c) 2023 Melanie C. Alden https://creativecommons.org/licenses/by/4.0
date: 2023-01-01
publication date: 2023-01-01
starting page: 1
ending page: 5
doi: 10.61784/wjcs231242

PROGRESS IN PHYSICAL THERAPY FOR DRY EYE DISEASE
type: item
description: In recent years, with the continuous development of information technology, people are generally overtired when using their eyes, so that the incidence of dry eye syndrome continues to increase, which has a great impact on patients' daily life. Life and work have had varying degrees of negative impact. Dry eye syndrome is a common ocular surface disease in clinical practice. At present, clinical medicine has developed a variety of treatments. Treatment methods and methods. Based on this, this article summarizes the research progress of physical therapy for dry eye disease, and analyzes the fumigation, atomization, eye massage, hot compress, wet room The effectiveness of traditional physical methods such as lenses in treating dry eye disease, With new bandage lenses and scleral contact lenses, LipiFlow thermal pulsation therapy, intense pulsed light therapy. The therapeutic effects of modern physical methods such as wet chamber heating goggles are hoped to serve as a reference for research in this field.
subject: Research Article
  topic: section
subject: Dry eye syndrome
  topic: keywords
subject: Physical therapy
  topic: keywords
subject: Research progress
  topic: keywords
creator: Christine Sharp
rights: Copyright (c) 2023 Christine Sharp https://creativecommons.org/licenses/by/4.0
date: 2023-01-01
publication date: 2023-01-01
starting page: 6
ending page: 8
doi: 10.61784/wjcs231243

REFLUX IN THE ELDERLY ESOPHAGUS CLINICAL INFLAMMATION RESEARCH STUDY ENTER EXHIBITION
type: item
description: Reflux esophagitis (RE) in the elderly It is a digestive tract dysfunction disease characterized by acid reflux and heartburn, which seriously affects the elderly. patient's quality of life. In recent years, research on gastroesophageal reflux disease has continued to deepen, making the elderly RE also received widespread attention. This article will start from the elderly RE The pathogenesis, Western medicine treatment and traditional Chinese medicine treatment are reviewed to improve the clinical understanding of the elderly re-understanding.
subject: Research Article
  topic: section
subject: Reflux esophagitis
  topic: keywords
subject: Gastroesophageal reflux disease
  topic: keywords
subject: Pathogenesis
  topic: keywords
subject: Treat
  topic: keywords
subject: Overview
  topic: keywords
creator: Nancy Gange
rights: Copyright (c) 2023 Nancy Gange https://creativecommons.org/licenses/by/4.0
date: 2023-01-01
publication date: 2023-01-01
starting page: 9
ending page: 12
doi: 10.61784/wjcs231244

RESEARCH PROGRESS ON BREAST RECONSTRUCTION IN PATIENTS WITH BREAST CANCER
type: item
description: Breast reconstruction after mastectomy for breast cancer patients plays an important role in improving the patient's quality of life. This article examines the cognition, attitude, and behavior of breast cancer patients regarding breast reconstruction. The current situation, influencing factors and improvement strategies are reviewed. Influencing factors include demographic factors (Age, place of residence, education level, occupation, marital status, family family financial status, health insurance type, race/ethnicity), clinical factors (cancer stage, whether received radiation therapy, quality of life, type of mastectomy), patients lack knowledge about breast reconstruction knowledge (Weak awareness of breast reconstruction and insufficient preoperative education), the countermeasures mainly include standardizing and popularizing multi-level education on breast reconstruction, establishing a correct understanding of breast reconstruction among patients, and strengthening social Support and formulate relevant policies to promote breast reconstruction, aiming to promote the knowledge, belief and practice of breast reconstruction among breast cancer patients in China and provide a basis for research.
subject: Research Article
  topic: section
subject: Breast cancer
  topic: keywords
subject: Breast reconstruction
  topic: keywords
subject: Knowledge
  topic: keywords
subject: Belief and action
  topic: keywords
subject: Influencing factors
  topic: keywords
subject: Care
  topic: keywords
creator: Kathleen Hessol
rights: Copyright (c) 2023 Kathleen Hessol https://creativecommons.org/licenses/by/4.0
date: 2023-01-01
publication date: 2023-01-01
starting page: 13
ending page: 20
doi: 10.61784/wjcs231245

RESEARCH PROGRESS ON CLINICAL APPLICATION AND SAFETY MANAGEMENT OF TOPIRAMATE
type: item
description: Topiramate is a broad-spectrum anti-epileptic drug (anti-epileptic drugs, AED) with multiple mechanisms of action, which is widely used in the treatment of various types of epilepsy and epilepsy syndromes. How to correctly select effective AEDs and balance the relationship between drug efficacy and adverse reactions has always been a key issue in clinical practice. This article describes the research progress of topiramate's clinical application, mechanism and safety management, including cognitive impairment, nephrolithiasis and sudomotor dysfunction. This article reviews the research progress on the clinical application and safety management of topiramate, including cognitive impairment, kidney stones and sudomotor dysfunction.
subject: Research Article
  topic: section
subject: Topiramate
  topic: keywords
subject: Epilepsy
  topic: keywords
subject: Clinical application
  topic: keywords
subject: Safety management.
  topic: keywords
creator: Zhuqing Sha
rights: Copyright (c) 2023 Zhuqing Sha https://creativecommons.org/licenses/by/4.0
date: 2023-01-05
publication date: 2023-01-05