ROLE OF APE1/REF-1 IN CARDIOVASCULAR DISEASES

Authors

  • Runmin Guo Department of Medicine, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan,528300, P.R. China Matenal and Child Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan,528300, P.R. China
  • Yue Wei Department of Ultrasound, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan,528300, P.R. China
  • Guoda Ma Matenal and Child Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan,528300, P.R. China
  • Jinfeng Zhang Newborns' diseases screening center, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan City, 528300, Guangdong, P.R. China
  • Zhiqiang Wang (Corresponding Author) Matenal and Child Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan,528300, P.R. China Clinical Research Center, the Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, P.R. China

Keywords:

APE1/Ref-1, cardiovascular diseases, base excision repair, redox regulation

Abstract

Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a multifunctional protein involved in the DNA base excision repair pathway, redox regulation, inflammation, and survival pathways. APE1/Ref-1 could inhibit the production of reactive oxygen species (ROS). Excessive ROS production could lead to DNA damage and cell apoptosis, which is viewed as the cause of cardiovascular diseases. Recent advances of molecular studies have demonstrated that APE1/Ref-1 is involved in the pathogenesis of cardiovascular diseases. In this review, we will introduce the multifunctional role of APE1/Ref-1 and its potential usefulness as a therapeutic target in cardiovascular diseases.

References

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Published

2020-04-09

Issue

Vol. 3 No. 1 (2020)

Section

Research Article

How to Cite

Runmin Guo, Yue Wei, Guoda Ma, Jinfeng Zhang, Zhiqiang Wang. Role Of Ape1/Ref-1 In Cardiovascular Diseases. Acta Translational Medicine. 2020, 3(1): 15-23.