INTRATHECAL DEXMEDETOMIDINE AS AN ADJUVANT TO BUPIVACAINE FOR SPINAL ANAESTHESIA FOR ELECTIVE CESAREAN SECTION: A RANDOMISED DOUBLE-BLIND CONTROLLED STUDY

Authors

  • Yanjun Chen 1 Department of Anesthesia, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China. 2 Department of obstetrics, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Zhenyun Yi 1 Department of Anesthesia, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China. 2 Department of obstetrics, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Shikai Wu Department of Anesthesia, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Hongbin Deng Department of Anesthesia, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Jin Miu Department of obstetrics, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Jia Liu Department of obstetrics, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Hao Wang Department of Anesthesia, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Yu-yong Liu (Corresponding Author) Department of Anesthesia, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China

Keywords:

Dexmedetomidine, Bupivacaine, Intrathecal, Lower segment cesarean section

Abstract

Objective: This study was designed to evaluate dexmedetomidine (Dex) 5ug as adjuvant combined with 0.5% bupivacaine 10 mg in elective Lower segment cesarean section (LSCS) with respect to the effect on parturients and newborns. Methods: Eighty parturients (ASAⅠ-Ⅱ) undergoing elective LSCS were assigned to 2 groups (n=40) to receive either 0.5% bupivacaine 10 mg with saline (Group C) or 0.5% bupivacaine 10mg with Dex 5ug (Group D). Adverse effects, hemodynamic parameters, Ramsay scores, VAS scores and neonatal Apgar scores were recorded. Umbilical artery blood was collected for blood gas analysis and measuring the levels of umbilical artery blood catecholamine. Data obtained were compiled and analyzed with appropriate tests, p＜0.05 was considered significant. Results: Compared with group C, the VAS score of group D was significant lower at T4（p＜0.05）; The incidence rates of Chill, Nausea, vomit of group D were lower than that in group C（p＜0.05）; This study revealed that the levels of umbilical artery blood lactic acid(Lac) ，Epinephrine (EPI) and Norepinephrine (NA) of group D were obvious lower than that in group C（p＜ 0.05）; MAP, HR, SPO2, Apgar score and Ramsay score did not show statistical difference between the two groups. Conclusions: The addition of 5ug Dex as an intrathecal adjuvant to bupivacaine for elective LSCS provides better analgesia without significant adverse effects, and also reduce the incidence of chill, nausea, vomit during operation.

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Published

2020-05-14

Issue

Vol. 3 No. 1 (2020)

Section

Research Article

How to Cite

Yanjun Chen, Zhenyun Yi, Shikai Wu, Hongbin Deng, Jin Miu, Jia Liu, Hao Wang, Yu-yong Liu. Intrathecal Dexmedetomidine As An Adjuvant To Bupivacaine For Spinal Anaesthesia For Elective Cesarean Section: A Randomised Double-Blind Controlled Study. Acta Translational Medicine. 2020, 3(1): 24-33.