COMPARISON OF THE DIAGNOSTIC PERFORMANCE OF 2D AND 3D MR IMAGES IN STAGING AND HISTOPATHOLOGY FINDINGS OF LOCALLY ADVANCED CERVICAL CANCER

Abstract

Objective: To compare three-dimensional (3D) volume measurement versus two-dimensional (2D) measurement during MR assessment of pre-treatment locally advanced cervical cancer, and to investigate the association of measurement outcomes with the staging of the tumor and histopathological feature in locally advanced cervical cancer. Methods: 46 patients were found having locally advanced cervical cancer that was confirmed by pathology (39 squamous cell carcinoma,7 adenomatous carcinoma). All patients were scanned by conventional MR scan, DCE-MR, and DWI sequence. Measurement results were compared between normal tissues and cervical cancer tissues in 3D and 2D. The association of measurement outcomes of 3D and 2D with the pathological grade and clinical stage of cervical cancer was explored. Results: There was no statistically significant difference between the results of 3D volume measurements and 2D diameter measurements (P>0.05). A significant correlation was found between the 3D volume measurement and cervical cancer stages (P<0.05). There was no correlation between 2D measurements and the clinical stage of cervical cancer (P>0.05). The outcomes between 3D volume measurement and 2D diameter measurement(The short cross-sectional diameter) among different histopathological grading of cervical cancer had statistical significance (P<0.05). Conclusion:3D volume measurement is more effective compared with 2D diameter measurement in MR assessment of locally advanced cervical cancer. In locally advanced cervical cancer, 3D volume measuring correlates with pathological grading and clinical stage. It provides more accurate and comprehensive data on pre-treatment cervical cancer. Therefore, 3D volume measurement can be used in preoperative MR imaging to monitor response to therapy and improve radiomics features analysis in patients with locally advanced cervical cancer.