RESEARCH PROGRESS ON FENTANYL-LIKE SUBSTANCES

Authors

  • Witold Ryan (Corresponding Author) Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688, Krakow, Poland.

Keywords:

Fentanyl, Fentanyl-like substances, Drug abuse, Pharmacological and toxicological effects, Detection methods, Drug control

Abstract

Fentanyl-like substances are a class of synthetically powerful anesthetics represented by fentanyl. In recent years, the abuse and trafficking situation has been severe in many countries around the world, posing a great threat to people's health and social stability. By reviewing the abuse, pharmacological and toxicological effects, detection methods and control conditions of fentanyl-like substances, we can improve people's understanding of their basic properties, research status and control conditions, and provide reference for future research.

References

[1] Chu YL. The expansion situation and prevention and control strategy offentanyl substance abuse. J Beijing Police College, 2019(3): 109-115.

[2] Yang LH. Reflection on the management of the whole class of fentanyl substances in China. J Yunnan Police Officer Academy, 2019(4): 1-4.

[3] Liu ZM. Abuse and control offentanyl and its derivatives: hazards and challenges. Chin J Drug Depend, 2017, 26(4): 274-276.

[4] UNODC. Fentanyl and its anolognes-50 year on. Global SMART Update, 2017, 17: 3-8.

[5] Karila L, Marillier M, Chaumette B. New synthetic opioids: part of a new addiction landscape. Neurosci Biobehav Rev, 2019, 106: 133-140.

[6] Baumann MH, Pasternak GW. Novel synthetic opioids and overdose deaths: tip of the iceberg? Neuropsychopharmacology, 2018, 43(1): 216-217.

[7] UNODC. Understanding the global opioid crisis. Global SMART Update, 2019, 21: 6-9.

[8] Burns SM, Cunningham CW, Mercer SL. DARK classics in chemical neuroscience: fentanyl. ACS Chem Neurosci, 2018, 9(10): 2428-2437.

[9] Comer SD, Cahill CM. Fentanyl: receptor pharmacology, abuse potential, and implications for treatment. Neurosci Biobehav Rev, 2019, 106: 49-57.

[10] Xiao JZ. Pharmacology and clinical practice of remifentanil. J Med Theor Pract, 2009, 22(2): 158-160.

[11] Yang S, Xu Q. Research progress in the fentanyl and its derivatives in the treatment of cancer pain. Shanghai Med Pharm J, 2015(5): 32-36.

[12] Pacifici GM. Clinical pharmacology of fentanyl in preterm infants. A review. Pediatr Neonatol, 2015, 56(3): 143-148.

[13] Schaefer CP, Tome ME, Davis TP. The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse. Fluids Barriers CNS, 2017, 14(1): 32.

[14] Ninkovi? J,Roy SRole of the mu-opioid receptor in opioid modulation of immune function. Amino Acids,2013,45(1): 9-2

[15] Xu L, Li YH. Studies on pharmacological action and clinical application of sufentanil. Anhui Med Pharm J, 2011(3): 375-377.

[16] Xiao GF, Lv H. Observation on the analgesic effect and stress state of brachial plexus block combined with remifentanil during replantation of severed fingers. J Logist Univ PAPF , 2018, 27(6): 48-51.

[17] Ma L, Wang XL. Evaluation of sufentanil in intravenous postoperative analgesia and clinical anesthesia. Gen J Stomat, 2018, 5(32): 191-192.

[18] Dumas EO, Pollack GM. Opioid tolerance development: a pharmacokinetic/pharmacodynamic perspective. AAPS J, 2008, 10(4): 537-551.

[19] Sutou I, Nakatani T, Hashimoto T. Fentanyl tolerance in the treatment of cancer pain: a case of successful opioid switching from fentanyl to oxycodone at a reduced equivalent dose . J Pain Palliat Care Pharmacother, 2015, 29(2): 161-165.

[20] Neunhoeffer F, Hanser A, Esslinger M. Ketamine infusion as a counter measure for opioid tolerance in mechanically ventilated children: a pilot study. Paediatr Drugs, 2017, 19(3): 259-265.

[21] Volkow ND, Jones EB, Einstein EB. Prevention and treatment of opioid misuse and addiction: a review. JAMA Psychiatry, 2019, 76(2): 208-216.

[22] Hao W, Zhao M, Li J. Addication medicine: theory and practice. Beijing: People's Medical Publishing House, 2016: 14-71.

[23] Aceto M. Dependence studies of new compounds in the rhesus monkey, rat and mouse. Problems Drug Dependence , 1996, 1998: 338.

[24] Pan LS, Cui YY, Ren YH. Dependence -producing potential of remifentanil. Chin J Drug Depend, 2002, 11(2): 107-110.

[25] Bekhit MH. Opioid-induced hyperalgesia and tolerance. Am J Ther, 2010, 17(5): 498-510.

[26] YueK, WenRJ. Neuroimmune mechanism of opiates addiction . J Jianghan Univ(Nat Sci Ed. ), 2017, 45(3): 241-246.

[27] Essawi MY. Fentanyl analogues with a modified propanamido group as potential affinity labels: synthesis and in vivo activity . Pharmazie, 1999, 54(4): 307-308.

[28] Lin H, Higgins P, Loh HH. Bidirectional effects offentanyl on dendritic spines and AMPA receptors depend upon the internalization of mu opioid receptors. Neuropsychopharmacology, 2009, 34(9): 2097-211.

[29] Wei X, Wei W. Role of gabapentin in preventing fentanyl-and morphine-withdrawal-induced hyperalgesia in rats. JAnesth, 2012, 26(2): 236-241.

[30] Dolinak D. Opioid toxicity. Acad Forensic Pathol, 2017, 7 (1): 19-35.

[31] Liu C, Kang Y. How to evaluate and select sedatives and analgesics considering their cardiovascular and respiratory effects? Chin J Crit Care Intensive Care Med Electron Ed, 2017, 3(4): 291-295.

[32] Liu XB, Xu GP. Research progress of mechanism about remifentanil slowing down heart rate. Med Recap, 2012, 18(23): 4027-4029.

[33] Chen L, Zhao YH, Liu XL. Progress in the application of sufentanil in the treatment of cancer pain. Chin J Pain Med, 2018, 24(11): 65-68.

[34] Guo ZF. Clinical application of sufentanil. J Chengde Med Col, 2016, 33(6): 516-519.

Published

2024-01-01

How to Cite

Ryan, W. (2024). Research Progress On Fentanyl-Like Substances. Eurasia Journal of Science and Technology, 6(1), 6-12. https://doi.org/10.61784/jpmr240123