META-ANALYSIS OF STATINS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH PULMONARY HYPERTENSION
Keywords:
Chronic obstructive pulmonary disease, Statins, Meta analysisAbstract
Objective To systematically evaluate the meta-analysis of statins in the treatment of chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension (PH). Methods: Systematically searching PubMed,CBM, VIP and Wanfang databases, and comprehensively collecting randomized controlled trials (RCT) of statins in the treatment of chronic obstructive pulmonary disease with pulmonary hypertension. According to the inclusion and exclusion criteria, literatures were screened, Meta were extracted and methodological quality was evaluated, and meta-analysis was performed by RevMan 5. 0 software. Results: Seven RCTs were included, with a total of 356 patients. Including 2 placebo-controlled trials and 5 non-placebo-controlled trials. Meta-analysis showed that: ① statin could improve the mean pulmonary arterial pressure (mPAP) [MD=-3. 83 mmHg, 95% ,CI(-5. 2, -2. 43)}, and the pulmonary arterial systolic pressure (PASP) [MD =-5. 66 mmhg, 95%, cl (-7 ... ②statin can significantly reduce the endothelin -1( ET-1) value [MD =-3. 51 pg/m1, 95% Cl, (-4. 77,-2. 55)] and increase the nitric oxide (NO) value [SMD = 1. 06,95%, CI (0 .. ③statin can improve the percentage of forced expiratory volume in the first second (FEV,%) [MD = 2. 92,95%, CI (-2.83,8.68)]. Conclusion: Statins can significantly improve pulmonary artery pressure, pulmonary function and clinical efficacy in COPD patients with PH.References
[1] Jiang Jiajia, Feng Jing, Dai Rong, et al. Meta-analysis of therapeutic effect of statins on chronic obstructive pulmonary disease complicated with pulmonary hypertension. Medical Herald, 2017.
[2] Yu Fengxia, Li Yuanyuan, Yu Shuhui, Hook. Meta-analysis of fasudil injection in treating chronic obstructive pulmonary disease complicated with pulmonary hypertension. Journal of Medical Research, 2012, 44(9):5.
[3] Zhao Yuling, Dong Ya, Fan Yali, et al. Meta-analysis of clinical efficacy of azithromycin combined with simvastatin in the treatment of chronic obstructive pulmonary disease complicated with pulmonary hypertension. Journal of Practical Cardiopulmonary Vascular Diseases, 2018, 26(03):8-12.
[4] Zhang Jing, Cha Zhaoyu, Wang Chunyan. Meta-analysis of simvastatin in treating patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension. Guizhou Medicine, 2016, 40(003):282-284.
[5] Zhang Yuqing, Feng Jing. Systematic evaluation of the therapeutic effect of statins on chronic obstructive pulmonary disease complicated with pulmonary hypertension and its adverse reactions based on gene polymorphism. Chongqing Medical University, 2010.
[6] Ouyang Zhicheng. Systematic evaluation of azithromycin combined with simvastatin in the treatment of chronic obstructive pulmonary disease complicated with pulmonary hypertension. Nanchang University; Medical college of nanchang university, 2017.
[7] Feng Jing. Systematic evaluation of the therapeutic effect of statins on chronic obstructive pulmonary disease complicated with pulmonary hypertension and its adverse reactions based on gene polymorphism. Chongqing Medical University.
[8] Wang Lingling, Shi Hanyu, Dong Yan, Wei Luqing, et al. Meta-analysis of pulmonary fibrosis complicated with emphysema syndrome complicated with pulmonary hypertension. Chinese Journal of Pulmonary Diseases, 2011, 012(003):289-295.
[9] Han Bei. Meta-analysis of efficacy and safety of prostacyclins in the treatment of pulmonary hypertension. Central South University, 2010.
[10] Zheng Jincong, Lin Wangchun, Li Ailin. Systematic evaluation of the efficacy of Fasudil in the treatment of chronic obstructive pulmonary disease with pulmonary hypertension. Evaluation and Analysis of Drug Use in China Hospital, 2019(6).
[11] Anonymous. A systematic review of azithromycin combined with simvastatin in the treatment of chronic obstructive pulmonary disease with pulmonary hypertension. 2018.
[12] Lue Wang Li, Ma Xun, Tao Jun, et al. Meta-analysis of pulmonary thromboendarterectomy in the treatment of chronic embolic pulmonary hypertension. 2016.
[13] Wang Fahui, Lin Shining, Chen Shan, et al. Analysis of therapeutic value of azithromycin combined with simvastatin on chronic obstructive pulmonary disease complicated with pulmonary hypertension. Proceedings of the 2016 Academic Annual Meeting of China Hospital Pharmacy Journal. 2016.
[14] Wan Jing, Wang Xinhua, Chen Xiaoyan, et al. Meta- analysis of the efficacy and safety of high-dose sildenafil in the treatment of neonatal persistent pulmonary hypertension. Chinese Science and Technology Information Catalogue-Chinese Herbal Medicine, 2020(006):043.
[15] LeeTM, Zhang Ying, Jin Chunyan, liu hongyan, Zhou Hui, Ning Jie. Meta-analysis of therapeutic effect of fasudil on pulmonary hypertension. Modern Medicine and Clinical, 2009.
[16] Cao Yanhong. Cao Yanhong's treatment analysis of chronic obstructive pulmonary disease complicated with pulmonary hypertension, 2012.
[17] Treatment analysis, Bosentan. Clinical treatment analysis of patients with congenital heart disease complicated with pulmonary hypertension. Ct diagnosis of pneumonia, 2015.
[18] ZHAOKao-chang, Chen Guozhong, Zhao Kao-Chang, et al. Meta-analysis of therapeutic effects of statins on patients with chronic obstructive pulmonary disease. Hainan Medical, 2015, 26(2):5.
[19] He Fang, Liu Meicheng, Qin Qin. Meta-analysis of long-term use of statins to reduce the risk of death and pulmonary artery pressure in COPD patients. Journal of Pharmacoepidemiology, 2018, 27(12):8.
[20] Zheng Jincong, Lin Wangchun, Li Ailin. Systematic evaluation of the efficacy of Fasudil in the treatment of chronic obstructive pulmonary disease with pulmonary hypertension. Evaluation and Analysis of Drug Use in China Hospital, 2019, 19(6):5.
[21] Zhen Ling, Li Lu, Liu Jiyang, et al. Systematic review of low-dose azithromycin combined with simvastatin in the treatment of chronic obstructive pulmonary disease with pulmonary hypertension. chinese journal of modern applied pharmacy, 2018, 35(1):6.
[22] Cui Xiaojiao. A reticular meta-analysis of the therapeutic effect of statins on COPD with pulmonary hypertension.
[23] Chen Cong, Chen Yuzhen, Li Tao. Meta-analysis of statins combined with sildenafil in the treatment of pulmonary hypertension. Today Pharmacy, 2018, 28(3):7.
[24] Zhao Shanshan, Qin Fang, Li Jing. Meta-analysis of alprostadil in the treatment of patients with chronic pulmonary heart disease and pulmonary hypertension. clinical medication journal, 2019, 17(1):6.
[25] Tang Yanfen Yin Tiping. Analysis of virus infection and biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease. Wannan Medical College, 2010.
[26] Liu Yang. meta-analysis of clinical efficacy of traditional Chinese medicine in treating COPD complicated with pulmonary hypertension. Liaoning University of Traditional Chinese Medicine, 2018.
[27] Meng Xiaohua. Meta-analysis of short-term efficacy and safety of inhaled nitric oxide in the treatment of children with congenital heart disease complicated with pulmonary hypertension after operation. Guangxi Medical University, 2012.
[28] He Bing. Meta-analysis of randomized controlled trials of drug therapy for pulmonary hypertension. Wuhan University, 2011.
[29] Liu Fang. Meta-analysis of statins in treating pulmonary hypertension. Shandong Uni