MACROPHAGES IN ACUTE MYOCARDIAL INFARCTION: HETEROGENEITY AND TARGETED THERAPIES
Keywords:
Myocardial infarction, Macrophages, Ventricular remodeling, ImmunotherapyAbstract
Cardiac repair after acute myocardial infarction depends on the precise regulation of the immune microenvironment. Macrophages are now understood beyond the M1/M2 dichotomy, with dual origins and a continuous functional spectrum. This review summarizes the spatiotemporal roles of cardiac resident and monocyte-derived macrophages, as well as their coordination in the resolution of inflammation, tissue repair, and scar maturation. It also outlines new therapeutic strategies targeting the recruitment of macrophages, their phenotypic transition, and metabolic reprogramming to improve post-infarction cardiac remodeling.References
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