CURRENT STATUS OF CLINICAL USE OF ANTIBACTERIAL DRUGS AND RESEARCH ON COUNTERMEASURES AGAINST DRUG RESISTANCE
Keywords:
Antibacterial drugs, Clinical application, Drug resistance, Rational useAbstract
Antimicrobial drugs are the main means of treating bacterial infections in clinical practice and play an important role in protecting human health. However, with the large-scale use and even rampant abuse of antimicrobial drugs in the medical, animal husbandry, and agricultural fields, the problem of bacterial resistance is becoming increasingly intractable and has now evolved into a global public health crisis. This article analyzes the current status and characteristics of the clinical application of antimicrobial drugs, explores the diverse mechanisms and harms of drug resistance, and proposes systematic prevention and control measures from multiple levels, including medical standards, technological innovation, and policy supervision, based on the latest research results and management experience at home and abroad. The aim is to provide theoretical basis and practical reference for preventing the spread of drug resistance and enhancing the level of rational use of antimicrobial drugs.References
[1] Wu Siqi, Rong Huijuan, Zhang Jingrui, et al. Analysis of pathogens isolated in a maternity hospital and their drug resistance trends. Chinese Journal of Disinfection, 2018, 35(10): 770-772.
[2] Wang Liangmin, Ji Kun, Shi Liqing, et al. Dynamic analysis of distribution characteristics and drug resistance of clinical isolates in hospitals from 2015 to 2017. Chinese Journal of Nosocomial Infection, 2018, 28(24): 67-70, 83-84.
[3] Pan Haiyan, Xiang Yonghong, Lü Cong. Distribution and drug resistance monitoring analysis of clinically isolated pathogens in our hospital from 2013 to 2015. China Medical Herald, 2018, 15(20): 166-168.
[4] Li Y, Sun QL, Shen Y, et al. Rapid increase in prevalence of carbapenem-resistant Enterobacteriaceae (CRE) and emergence of colistin resistance gene mcr-1 in CRE in a hospital in Henan, China. J Clin Microbiol, 2018, 56(4): e01932-17.
[5] Gu Zheng, Wu Mingfen, Sun Aning. Bibliometric analysis of fluoroquinolone antimicrobial resistance research based on CiteSpace. China Pharmaceutical Industry, 2025, 34(15): 51-57.
[6] Wang Qilin. Characteristics of major pathogens in urological patients and their resistance to antimicrobial drugs. Chinese Practical Medicine, 2025, 20(11): 71-74. DOI: 10.14163/j.cnki.11-5547/r.2025.11.017.
[7] You Shunjie, Jia Aimin, Li Si, et al. Research progress on reversing antimicrobial resistance in MRSA. Hebei Medical Journal, 2025, 47(02): 307-312.
[8] Cui Runbo, Chen Miaomiao, Hong Shouqiang, et al. Research progress on the mechanism of disinfectant promoting the generation and spread of antimicrobial resistance in bacteria. Chinese Journal of Antibiotics, 2025, 50(02): 160-170.