APPLICATION PROGRESS OF GENE THERAPY IN THE FIELD OF REGENERATIVE MEDICINE
Keywords:
Gene therapy, Regenerative medicine, Tissue repairAbstract
Regenerative medicine is based on the structure and function of tissues to repair and treat affected areas . A discipline that damages tissues and organs . The emergence and development of regenerative medicine provides new ideas for the treatment of diseases and alleviates the shortage of transplanted tissues and organs . The problem . The process of tissue and organ regeneration is very complex and requires stable environment . Stable cytokine expression is a key factor in tissue and organ regeneration , and gene therapy can effectively solve this problem . Gene therapy The seed cells of the therapy can stably and continuously secrete the cytokines required for regeneration , provide a stable local environment , and improve the efficiency of tissue repair . therefore , Gene therapy will produce more ideal results in the field of regenerative medicine Treatment Effect .References
[1] Kaufmann KB, Buning H, Galy A, et al. EMBO molecular medicine, 2013, 5(11): 1642-1661.
[2] Kimelman Bleich N, Kallai I, Lieberman JR, et al. Gene therapy ap- proaches to regenerating bone. Advanced drug delivery reviews, 2012, 64(12): 1320-1330.
[3] Thybo KH, Eskesen V. The most important reason for lack of organ do- nation is family refusal. Danish medical journal, 2013, 60(2): A4585.
[4] Jarvinen TA, May U, Prince S. Systemically Administered, Target Or- gan-Specific Therapies for Regenerative Medicine. International journal of molecular sciences, 2015, 16(10): 23556-23571.
[5] Southwood LL, Kawcak CE, Hidaka C, et al. Evaluation of direct in vi- vo gene transfer in an equine metacarpal IV ostectomy model using an adenoviral vector encoding the bone morphogenetic protein-2 and protein-7 gene. Veterinary surgery, 2012, 41(3): 345-354.
[6] Ishihara A, Zekas LJ, Litsky AS, et al. Dermal fibroblast-mediated BMP2 therapy to accelerate bone healing in an equine osteotomy model. Journal of orthopaedic research, 2010, 28(3): 403-411.
[7] Rakoczy EP, Narfstrom K. Gene therapy for eye as regenerative medi- cine? Lessons from RPE65 gene therapy for Leber’s Congenital Amau- rosis. The international journal of biochemistry & cell biology, 2014(56): 153-157.
[8] Cisternas P, Henriquez JP, Brandan E, et al. Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis.Molecular neurobiology, 2014, 49(1): 574-589.
[9] Evans CH, Huard J. Gene therapy approaches to regenerating the mus- culoskeletal system. Nat Rev Rheumatol, 2015, 11(4): 234-242.
[10] Han Xiangzhen, He Huiyu, Hu Yang, etc. human bone morphogenetic protein -2 Recombinant lentiviral vector Transfection of sheep bone marrow mesenchymal stem cells and their osteogenic regulatory effects. Chinese Journal of Practical Diagnosis and Treatment, 2014, 28(6): 540-542.
[11] Ishihara A, Zekas LJ, Litsky AS, et al. Dermal fibroblast-mediated BMP2 therapy to accelerate bone healing in an equine osteotomy model. Journal of orthopaedic research: official publication of the Orthopaedic Research Society, 2010, 28(3): 403-411.
[12] Rincon MY, VandenDriessche T, Chuah MK. Gene therapy for cardio- vascular disease: advances in vector development, targeting, and de- livery for clinical translation. Cardiovascular research, 2015, 108(1): 4-20.
[13] Olea FD, De Lorenzi A, Cortes C, et al. Combined VEGF gene trans- fer and erythropoietin in ovine reperfused myocardial infarction.International journal of cardiology, 2013, 165(2): 291-298.
[14] Xue XD, Liu Y, Zhang J, et al. Bcl-xL Genetic Modification En- hanced the Therapeutic Efficacy of Mesenchymal Stem Cell Trans- plantation in the Treatment of Heart Infarction. Stem cells international, 2015(2015): 176409. doi: 10. 1155/2015/176409.
[15] Kantor B, McCown T, Leone P, et al. Clinical applications involving CNS gene transfer. Advances in genetics, 2014(87): 71-124.
[16] Mittermeyer G, Christine CW, Rosenbluth KH, et al. Long-term evalu- ation of a phase 1 study of AADC gene therapy for Parkinson’s dis- ease. Human Gene Therapy, 2012, 23(4): 377-381.
[17] LeWitt PA, Rezai AR, Leehey MA, et al. AAV2-GAD gene therapy for advanced Parkinson’s disease: a double-blind, sham-surgery con- trolled, randomised trial. Lancet Neurology, 2011, 10(4): 309-319.
[18] Wells A, Nuschke A, Yates CC. Skin tissue repair: Matrix micro environmental influences. Matrix Biology, 2015. doi: 10.1016/j.matbio.2015.08.001.
[19] Di WL, Larcher F, Semenova E, et al. Ex-vivo gene therapy restores LEKTI activity and corrects the architecture of Netherton syndrome- derived skin grafts. Molecular therapy: the journal of the American Society of Gene Therapy, 2011, 19(2):408-416.