STUDY ON BLOOD PROTEIN MARKERS OF ALZHEIMER’S DISEASE
Keywords:
Alzheimer's disease, Blood biomarkers, Ultra-sensitive detection technologyAbstract
Alzheimer's disease (AD) is a common degenerative disease of the central nervous system, and early diagnosis is very important for its treatment. However, clinical diagnosis currently requires invasive lumbar puncture or expensive Aβ/Tau PET examination, resulting in a lag in early diagnosis. Peripheral blood has the advantages of being non-invasive, easy to obtain, and suitable for disease tracking and follow-up. Over the years, research has been striving to find early specific biomarkers of AD in peripheral blood. However, due to the low concentration of brain-derived proteins in blood and their vulnerability to interference from plasma matrix proteins, previous studies using traditional enzyme-linked immunosorbent assay (ELISA) to detect AD-related proteins in blood have been inconsistent. In recent years, some ultra-sensitive detection technologies have been gradually applied to the study of AD blood protein markers. The relevant results show that Aβ, p-Tau and exosomes in blood have potential application value in the early diagnosis, identification and prediction of AD. Therefore, this article reviews the research progress of AD protein markers in blood in the past five years to improve the understanding of blood biomarkers in the diagnosis and treatment of AD and provide guidance for their better early clinical application.References
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