RESEARCH PROGRESS ON THE PATHOGENESIS AND CLINICAL MANIFESTATIONS OF COVID -19
Keywords:
COVID-19, Genome, Mechanism of infection, Clinical manifestationsAbstract
COVID-19 Since the outbreak in 2019, it has seriously affected global public health and is still epidemic in many countries. This review was approved by NCBI, CNKI, Web Search COVID-19 related literature in of Science, China National Knowledge Infrastructure and official reports to summarize and systematically explain the current COVID-19 genome characteristics. Research progress and existing deficiencies on the points, infection mechanism, and clinical characteristics, in order to provide new ideas and valuable reference materials for COVID -19 research and prevention and control.References
[1] CHAN J F W, YUAN S, KOK K H, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet, 2020. Doi: 10.1016/s0140-6736(20) 30154-9.
[2] COUTARD B, VALLE C, DE LAMBALLERIE X, et al. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. AntiviralRes, 2020, 176: 104742.
[3] WEI X, LI X, CUI J. Evolutionary perspectives on novel coronaviruses identified in pneumonia cases in China. Nat Sci Rev, 2020. Doi: 10.1093/nsr/nwaa009/5717501.
[4] JASPER FUK-WOO CHAN, KIN-HANG KOK, ZHENG ZHU, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emer- ging Microbes & Infections, 2020, DOI: 10.1080/22221751.2020.1719902.
[5] HANGPING YAO, XIANGYUN LU, QIONG CHEN, et al. Patient-derived mutations impact pathogenicity of SARS- CoV-2. BMJ. 2020. doi: http://doi.org/10.1101/2020.04.14.20060160.
[6] KORBER B, S FISCHER WM, GNANAKARAN S, et al. pike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2. https://doi.org/10.1101/2020.04.29.069054.
[7] LUCY VAN DORP, MISLAV ACMAN, DAMIEN RICH- ARD, et al. Emergence of genomic diversity and recurrent mutations in SARS-CoV-2. Infection, Genetics and Evolution. 2020. DOI: 10.1016/j.meegid.2020.104351.
[8] HAO WANG, ZIXUAN YUAN, MAHMUD ARIF PAVEL, et al. The role of high cholesterol in age related COVID-19 lethality. THE PREPRINT SERVER FOR BIOLOGY. 2020. DOI: http://doi.org/10.1101/2020.05.09.086249.
[9] ZHOU P, YANG X L, WANG X G, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 2020: 1-4.
[10] ZHOU P, YANG XL, WANG XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 2020, 579(7798): 270.
[11] XU X, CHEN P, WANG J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci, 2020, 63(3): 457.
[12] WRAPP D, WANG N, CORBETT KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion con- formation. Science, 2020, 367(6483): 1260.
[13] MUNSTER V J,KOOPMANS M,DOREMALEN N V,et al. A novel coronavirus emerging in China? key ques- tions for impact assessment.N Eng J Med,2020. Doi: 10.1056/NOMp 2000929.
[14] KE WANG, WEI CHEN, YU-SEN ZHOU, et al. SARSCoV-2 invades host cells via a novel route: CD147 - spike protein. bioRxiv. doi: https://doi. org/10. 1101/2020. 03. 14. 988345.
[15] BIAN H, et al. Meplazumab treats COVID-19 pneumoni- a: an open-labelled, concurrent controlled add-on clinical trial. 2020. DOI: 10. 1101/2020. 03. 21. 20040691.
[16] HUANG C, WANGY, LI X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020, pii: S0140 6736 (20) 30183-30185.
[17] WANG D, HU B, HU C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus infected pneumonia in Wuhan, China. JAMA, 2020, 323(11): 1061.
[18] WU J T, LEUNG K, LEUNG G M. Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study. Lancet (London, England ), 2020. doi: 10. 1016/s0140-6736 (20) 30260-9[pub- lished Online First: 2020/02/06].
[19] PENG PENG, YU HUI-SHAN, ZHOU XIN-HUA et al. Clinical features and CT imaging diagnosis of novel coronavirus pneumonia. J Tuberc Lung Health, 2020, 9(1): 11.
[20] LIU Y, YANG Y, ZHANG C, et al. Clinical and biochemical indexes from 2019-nCoV infected pati ents linked to viral loads and lung injury. Sci China Life Sci, 2020, 63(3): 364.
[21] HUANG C, WANG Y, LI X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wu- han, China. Lancet, 2020, 395(10223): 497.
[22] DENG W, BAO L, GAO H, et al. Rhesus macaques can be effectively infected with SARS-CoV-2 via ocular 1 conjunctival route. bioRxiv 2020 17 Chen L, Deng C, Chen X, et al. Ocular manifestations and clinical charac- teristics of 534 cases of COVID-19 in China: A cross- sectional study. med Rxiv 2020.
[23] CHEN L,DENG C,CHEN X,et al.Ocular manifestations and clinical character ristics of 534 cases of COVID1 in China: A crosssectiona l study.med Rxiv 2020.
[24] XIA J, TONG J, LIU M, et al. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol 2020.
[25] ZOU X, CHEN K, ZOU J, et al. Single-cell RNA-seq data a- nalysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019 - nCoV infection. Front Med 2020[Epub ahead of print]
[26] LI Z,WU M,GUO J,et al.Caution on Kidney Dysfunc tions of 2019nCoV patients Med Rxiv, 2020, DOI: 10,1101/2020/02/08/2
[27] FAN C, LI K, DING Y, et al. ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCoV Infection. med Rxiv, 2020, DOI: 10. 1101/2020. 02. 12. 20022418.