Author(s)

HongYan Ren^1,2, JianQuan Li^2*

Affiliation(s)

¹Medical School, Guizhou University, Guiyang 550000, Guizhou, China.

²Intensive Care Unit, Guizhou Provincial People's Hospital, Guiyang 550000, Guizhou, China.

Corresponding Author

JianQuan Li

ABSTRACT

Sepsis represents a severe dysregulation of the host response to infection. In recent years, the involvement of long non-coding RNAs (lncRNAs) in the onset and progression of sepsis has garnered significant attention. This review outlines the expression profiles and regulatory functions of lncRNAs in sepsis, emphasizing their associations with inflammatory processes, immune dysregulation, and organ injury. It highlights the molecular pathways through which lncRNAs influence sepsis by modulating inflammatory signaling, immune cell activities, and programmed cell death. Additionally, the potential utility of lncRNAs as diagnostic markers and therapeutic targets is discussed.

KEYWORDS

Long non-coding RNA; Sepsis; Inflammatory response; Immune regulation; Organ injury; Molecular mechanism

CITE THIS PAPER

HongYan Ren, JianQuan Li. Research progress on long non-coding RNA-mediated sepsis progression. Journal of Pharmaceutical and Medical Research. 2025, 7(2): 26-30. DOI: https://doi.org/10.61784/jpmr3041.

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