ROLE OF APE1/REF-1 IN CARDIOVASCULAR DISEASES
Download as PDFVolume 3, Issue 1, Pp 15-23, 2020
Author(s)
Runmin Guo1,2, Yue Wei3, Guoda Ma2, Jinfeng Zhang4, Zhiqiang Wang2,5*
Affiliation(s)
1Department of Medicine, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan,528300, P.R. China.
2Matenal and Child Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan,528300, P.R. China.
3Department of Ultrasound, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan,528300, P.R. China.
4Newborns' diseases screening center, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan City, 528300, Guangdong, P.R. China.
5Clinical Research Center, the Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, P.R. China.
Corresponding Author
Zhiqiang Wang
ABSTRACT
Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a multifunctional protein involved in the DNA base excision repair pathway, redox regulation, inflammation, and survival pathways. APE1/Ref-1 could inhibit the production of reactive oxygen species (ROS). Excessive ROS production could lead to DNA damage and cell apoptosis, which is viewed as the cause of cardiovascular diseases. Recent advances of molecular studies have demonstrated that APE1/Ref-1 is involved in the pathogenesis of cardiovascular diseases. In this review, we will introduce the multifunctional role of APE1/Ref-1 and its potential usefulness as a therapeutic target in cardiovascular diseases.
KEYWORDS
APE1/Ref-1, cardiovascular diseases, base excision repair, redox regulation
CITE THIS PAPER
Runmin Guo, Yue Wei, Guoda Ma, Jinfeng Zhang, Zhiqiang Wang. Role of APE1/Ref-1 in cardiovascular diseases. Acta Translational Medicine. 2020, 3(1): 15-23.
REFERENCES
[1] Demple B, Harrison L. Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem 1994; 63: 915-48. eng.
[2] D'Errico M, Parlanti E, Dogliotti E. Mechanism of oxidative DNA damage repair and relevance to human pathology. Mutat Res 2008; 659 (1-2): 4-14. eng.
[3] Bhakat KK, Mantha AK, Mitra S. Transcriptional Regulatory Functions of Mammalian APEndonuclease (APE1/Ref-1), an Essential Multifunctional Protein. Antioxid Redox Signal 2009; 11 (3): 621-37.
[4] Bauer CE, Elsen S, Bird TH. Mechanisms for redox control of gene expression. Annu Rev Microbiol 1999; 53: 495-523. eng.
[5] Tell G, Quadrifoglio F, Tiribelli C, Kelley MR. The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxid Redox Signal 2009; 11 (3): 601-20. eng.
[6] Xanthoudakis S, Miao GG, Curran T. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Natl Acad Sci USA 1994; 91 (1): 23-27. eng.
[7] Choi S, Joo HK, Jeon BH. Dynamic Regulation of APE1/Ref- 1 as a Therapeutic Target Protein. Chonnam Med J 2016; 52 (2): 75- 80.
[8] Moris D, Spartalis M, Spartalis E, Karachaliou G-S, Karaolanis GI, Tsourouflis G, et al. The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox. Annals of Translational Medicine 2017; 5 (16). en.
[9] Hegde ML, Mantha AK, Hazra TK, Bhakat KK, Mitra S, Szczesny B. Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev 2012; 133 (4): 157-68. eng.
[10] Thakur S, Dhiman M, Tell G, Mantha AK. A review on proteinprotein interaction network of APE1/Ref-1 and its associated biological functions. Cell Biochem Funct 2015; 33 (3): 101-12. eng.
[11] Mol CD, Izumi T, Mitra S, Tainer JA. DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]. Nature 2000; 403 (6768): 451-56. eng.
[12] Kanazhevskaya LY, Koval VV, Zharkov DO, Strauss PR, Fedorova OS. Conformational transitions in human AP endonuclease 1 and its active site mutant during abasic site repair. Biochemistry 2010; 49 (30): 6451-61. eng.
[13] Jackson EB, Theriot CA, Chattopadhyay R, Mitra S, Izumi T. Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). Nucleic Acids Res 2005; 33 (10): 3303-12. eng.
[14]Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK, et al. Regulatory role of human APendonuclease (APE1/Ref-1) in YB- 1-mediated activation of the multidrug resistance gene MDR1. Mol Cell Biol 2008; 28 (23): 7066- 80. eng.
[15] Luo M, Zhang J, He H, Su D, Chen Q, Gross ML, et al. Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease. Biochemistry 2012; 51 (2): 695-705. eng.
[16] Cesselli D, Aleksova A, Sponga S, Cervellin C, Di Loreto C, Tell G, et al. Cardiac Cell Senescence and Redox Signaling. Front Cardiovasc Med 2017; 4.Thakur S, Sarkar B, Cholia RP, Gautam N, Dhiman M, Mantha AK. APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions. Experimental & Molecular Medicine 2014; 46 (7): e106.
[17] Beckman KB, Ames BN. Oxidative decay of DNA. J Biol Chem 1997; 272 (32): 19633-
[18] 36. eng.
[19] Slupphaug G, Kavli B, Krokan HE. The interacting pathways for prevention and repair of oxidative DNA damage. Mutat Res 2003; 531 (1-2): 231-51. eng.
[20] Hegde ML, Hazra TK, Mitra S. Early Steps in the DNA Base Excision/Single-Strand Interruption Repair Pathway in Mammalian Cells. Cell Res 2008; 18 (1): 27-47.
[21] Doetsch PW, Cunningham RP. The enzymology of apurinic/apyrimidinic endonucleases. Mutat Res 1990; 236 (2-3): 173-201. eng.
[22] Xanthoudakis S, Miao G, Wang F, Pan YC, Curran T. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J 1992; 11 (9): 3323-35. eng.
[23] Abate C, Patel L, Rauscher FJ, Curran T. Redox regulation of fos and jun DNA-binding activity in vitro. Science 1990; 249 (4973): 1157-61. eng.
[24] Guan Z, Basi D, Li Q, Mariash A, Xia Y-F, Geng J-G, et al. Loss of redox factor 1 decreases NFkappaB activity and increases susceptibility of endothelial cells to apoptosis. Arterioscler Thromb Vasc Biol 2005; 25 (1): 96-101. eng.
[25] Martin KR, Barrett JC. Reactive oxygen species as double-edged swords in cellular processes: lowdose cell signaling versus highdose toxicity. Hum Exp Toxicol 2002; 21 (2): 71-75. eng.
[26] Ramana CV, Boldogh I, Izumi T, Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc Natl Acad Sci USA 1998; 95 (9): 5061-66. eng.
[27] Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, Prives C. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev 1997; 11 (5): 558-
[28] 70. eng.
[29] Hafsi H, Hainaut P. Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence. Antioxid Redox Signal 2011; 15 (6): 1655-67. eng.
[30] Maillet A, Pervaiz S. Redox regulation of p53, redox effectors regulated by p53: a subtle balance. Antioxid Redox Signal 2012; 16 (11): 1285-94. eng.
[31] Gaiddon C, Moorthy NC, Prives C. Ref-1 regulates the transactivation and pro- apoptotic functions of p53 in vivo. EMBO J 1999; 18 (20): 5609-21. eng.
[32] Members WG, Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, et al. Executive Summary: Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association. Circulation 2012; 125 (1): 188-97. en.
[33] Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90 (17): 7915-22. eng.
[34] D'Onofrio N, Servillo L, Balestrieri ML. SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection. Antioxid Redox Signal 2017.
[35] Farías JG, Molina VM, Carrasco RA, Zepeda AB, Figueroa E, Letelier P, et al.Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress. Nutrients 2017; 9 (9). eng.
[36] Aonuma T, Takehara N, Maruyama K, Kabara M, Matsuki M, Yamauchi A, et al. Abstract 12613: Apurinic/apyrimidinic Endonuclease/redox Factor-1 Gene Enhances Anti-apoptotic Function of Cardiac Progenitor Cells via TAK1-Activation and Promotes Cardiac Regeneration in Myocardial Infarction. Circulation 2015; 132 (Suppl 3): A12613-A13. en.
[37] Jin S-A, Seo HJ, Kim SK, Lee YR, Choi S, Ahn K-T, et al. Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease. Korean Circ J 2015; 45 (5): 364-71.
[38] Hou X, Yoshida T, Higashi Y, Shai SY, Kim C, Delafontaine P, et al. Abstract 15762: Gapdh Interaction With Ape1 Endonuclease Protects Vascular Smooth Muscle Cells Against Apoptosis: Potential Role of These Enzymes in Prevention of Atherosclerotic Plaque Destabilization. Circulation 2015; 132 (Suppl 3): A15762-A62. en.
[39] Sukhanov S, Yoshida T, Delafontaine P. GAPDH prevents oxidant-induced apoptosis in smooth muscle cells via upregulation of APE1/Ref-1 endonuclease (1093.1). FASEB J 2014; 28 (1 Supplement): 1093.1. en.
[40] Hou X, Snarski P, Higashi Y, Yoshida T, Jurkevich A, Delafontaine P, et al. Nuclear complex of glyceraldehyde-3- phosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells against oxidant- induced cell death. FASEB J 2017; 31 (7): 3179-92. eng.
[41] Yamauchi A, Kawabe J-i, Kabara M, Matsuki M, Asanome A, Aonuma T, et al. Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation. American Journal of Physiology - Heart and Circulatory Physiology 2013; 305 (8): H1158-H67. en.
[42]Kim CS, Son SJ, Kim EK, Kim SN, Yoo DG, Kim HS, et al. Apurinic/apyrimidinic endonuclease1/redox factor-1 inhibits monocyte adhesion in endothelial cells. Cardiovasc Res 2006; 69 (2): 520-26. eng.
[43] Patterson C. Blood Pressure Control Goes Nuclear. Circulation Research 2004; 95 (9): 849-51. en.
[44] Jeon BH, Gupta G, Park YC, Qi B, Haile A, Khanday FA, et al. Apurinic/Apyrmidinic Endonuclease 1 Regulates Endothelial NO Production and Vascular Tone. Circulation Research 2004; 95 (9): 902-10. en.
[45] Song SH, Cho EJ, Park MS, Lee YR, Joo HK, Kang G, et al. Redox Regulating Protein APE1/Ref-1 Expression is Increased in Abdominal Aortic Coarctationinduced Hypertension Rats. Journal of the Korean Society of Hypertension 2012; 18 (3): 126. ko.
[46] Naganuma T, Nakayama T, Sato N, Fu Z, Soma M, Yamaguchi M, et al. Haplotype- based case-control study on human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 gene and essential hypertension. Am J Hypertens 2010; 23 (2): 186-
[47] 91. eng.
[48] Sengupta S, Chattopadhyay R, Mantha AK, Mitra S, Bhakat KK. Regulation of mouse- renin gene by apurinic/apyrimidinic-endonuclease 1 (ape1/ref-1) via recruitment of histone deacetylase 1 corepressor complex. Journal of Hypertension 2012; 30 (5): 917-25. English.
[49] Huttner HB, Bergmann O, Salehpour M, Rácz A, Tatarishvili J, Lindgren E, et al. The age and genomic integrity of neurons after cortical stroke in humans. Nature Neuroscience 2014; 17 (6): 801-03. en.
[50] Li P, Leak R, Zhang F, Cao G, Gao Y, Chen J. Abstract 8: APE1 Upregulation Reduces Oxidative DNA Damage and Protects Hippocampal Neurons from Ischemic Injury. Stroke 2014; 45 (Suppl 1): A8-A8. en.
[51] Leak RK, Li P, Zhang F, Sulaiman HH, Weng Z, Wang G, et al. Apurinic/Apyrimidinic Endonuclease 1 Upregulation Reduces Oxidative DNA Damage and Protects Hippocampal Neurons from Ischemic Injury. Antioxid Redox Signal 2013; 22 (2): 135- 48.
[52] Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, et al. APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury. PNAS 2016; 113 (25): E3558-E67. en.
[53] Dyrkheeva NS, Lebedeva NA, Lavrik OI. AP Endonuclease 1 as a Key Enzyme in Repair of Apurinic/Apyrimidinic Sites. Biochemistry Mosc 2016; 81 (9): 951-67. eng.