Author(s)

Hong Wang¹, Liu Yang¹, HuaiGang Chen², GaoMing Hong³, ShengQiang Zeng¹, WenYan Xu^1,2, Yao Hu^1*

Affiliation(s)

¹Department of Cardiology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, China.

²Medical College of Nanchang University, Nanchang 330006, Jiangxi, China.

³The People’s Hospital of Yujiang District, Yingtan 335000, Jiangxi, China.

Corresponding Author

Yao Hu

ABSTRACT

To elucidate SFI’s protective mechanism against MIRI, this study identified the MAPK pathway via bioinformatics. Experimental validation in MIRI rats confirmed that SFI improves myocardial injury by suppressing MAPK activation and inflammatory factors (IL-1β, IL-6, TNF-α), supporting its clinical potential.

KEYWORDS

Shenfu Injection (SFI); Myocardial Ischemia-Reperfusion Injury (MIRI); Mitogen-Activated Protein Kinase (MAPK) signaling pathway; Bioinformatics; Inflammatory factors

CITE THIS PAPER

Hong Wang, Liu Yang, HuaiGang Chen, GaoMing Hong, ShengQiang Zeng, WenYan Xu, Yao Hu. Mechanism study of Shenfu Injection regulating MAPK pathway to alleviate myocardial Ischemia-Reperfusion Injury in rats based on bioinformatics and experimental verification. Journal of Pharmaceutical and Medical Research. 2025, 7(3): 15-19. DOI: https://doi.org/10.61784/jpmr3048.

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