APPLICATION PROGRESS OF GENE THERAPY IN THE FIELD OF REGENERATIVE MEDICINE
Volume 1, Issue 2, Pp 16-19, 2023
DOI:10.61784/wjbs231239
Author(s)
Navid Larson
Affiliation(s)
Ohio State University, John Glenn School of Public Affairs, Columbus, OH, United States.
Corresponding Author
Navid Larson
ABSTRACT
Regenerative medicine is based on the structure and function of tissues to repair and treat affected areas. A discipline that damages tissues and organs. The emergence and development of regenerative medicine provides new ideas for the treatment of diseases and alleviates the shortage of transplanted tissues and organs. The problem. The process of tissue and organ regeneration is very complex and requires stable environment. Stable cytokine expression is a key factor in tissue and organ regeneration, and gene therapy can effectively solve this problem. Gene therapy The seed cells of the therapy can stably and continuously secrete the cytokines required for regeneration, provide a stable local environment, and improve the efficiency of tissue repair. therefore, Gene therapy will produce more ideal results in the field of regenerative medicine Treatment Effect.
KEYWORDS
Gene therapy; Regenerative medicine; Tissue repair
CITE THIS PAPER
Navid Larson. Application progress of gene therapy in the field of regenerative medicine. World Journal of Biomedical Sciences. 2023, 1(2): 16-19. DOI:10.61784/wjbs231239.
REFERENCES
[1] Kaufmann KB, Buning H, Galy A, et al. EMBO molecular medicine, 2013, 5(11): 1642-1661.
[2] Kimelman Bleich N, Kallai I, Lieberman JR, et al. Gene therapy ap- proaches to regenerating bone. Advanced drug delivery reviews, 2012, 64(12): 1320-1330.
[3] Thybo KH, Eskesen V. The most important reason for lack of organ do- nation is family refusal. Danish medical journal, 2013, 60(2): A4585.
[4] Jarvinen TA, May U, Prince S. Systemically Administered, Target Or- gan-Specific Therapies for Regenerative Medicine. International journal of molecular sciences, 2015, 16(10): 23556-23571.
[5] Southwood LL, Kawcak CE, Hidaka C, et al. Evaluation of direct in vi- vo gene transfer in an equine metacarpal IV ostectomy model using an adenoviral vector encoding the bone morphogenetic protein-2 and protein-7 gene. Veterinary surgery, 2012, 41(3): 345-354.
[6] Ishihara A, Zekas LJ, Litsky AS, et al. Dermal fibroblast-mediated BMP2 therapy to accelerate bone healing in an equine osteotomy model. Journal of orthopaedic research, 2010, 28(3): 403-411.
[7] Rakoczy EP, Narfstrom K. Gene therapy for eye as regenerative medi- cine? Lessons from RPE65 gene therapy for Leber’s Congenital Amau- rosis. The international journal of biochemistry & cell biology, 2014(56): 153-157.
[8] Cisternas P, Henriquez JP, Brandan E, et al. Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis.Molecular neurobiology, 2014, 49(1): 574-589.
[9] Evans CH, Huard J. Gene therapy approaches to regenerating the mus- culoskeletal system. Nat Rev Rheumatol, 2015, 11(4): 234-242.
[10] Han Xiangzhen, He Huiyu, Hu Yang, etc. human bone morphogenetic protein -2 Recombinant lentiviral vector Transfection of sheep bone marrow mesenchymal stem cells and their osteogenic regulatory effects. Chinese Journal of Practical Diagnosis and Treatment, 2014, 28(6): 540-542.
[11] Ishihara A, Zekas LJ, Litsky AS, et al. Dermal fibroblast-mediated BMP2 therapy to accelerate bone healing in an equine osteotomy model. Journal of orthopaedic research: official publication of the Orthopaedic Research Society, 2010, 28(3): 403-411.
[12] Rincon MY, VandenDriessche T, Chuah MK. Gene therapy for cardio- vascular disease: advances in vector development, targeting, and de- livery for clinical translation. Cardiovascular research, 2015, 108(1): 4-20.
[13] Olea FD, De Lorenzi A, Cortes C, et al. Combined VEGF gene trans- fer and erythropoietin in ovine reperfused myocardial infarction.International journal of cardiology, 2013, 165(2): 291-298.
[14] Xue XD, Liu Y, Zhang J, et al. Bcl-xL Genetic Modification En- hanced the Therapeutic Efficacy of Mesenchymal Stem Cell Trans- plantation in the Treatment of Heart Infarction. Stem cells international, 2015(2015): 176409. doi: 10. 1155/2015/176409.
[15] Kantor B, McCown T, Leone P, et al. Clinical applications involving CNS gene transfer. Advances in genetics, 2014(87): 71-124.
[16] Mittermeyer G, Christine CW, Rosenbluth KH, et al. Long-term evalu- ation of a phase 1 study of AADC gene therapy for Parkinson’s dis- ease. Human Gene Therapy, 2012, 23(4): 377-381.
[17] LeWitt PA, Rezai AR, Leehey MA, et al. AAV2-GAD gene therapy for advanced Parkinson’s disease: a double-blind, sham-surgery con- trolled, randomised trial. Lancet Neurology, 2011, 10(4): 309-319.
[18] Wells A, Nuschke A, Yates CC. Skin tissue repair: Matrix micro environmental influences. Matrix Biology, 2015. doi: 10.1016/j.matbio.2015.08.001.
[19] Di WL, Larcher F, Semenova E, et al. Ex-vivo gene therapy restores LEKTI activity and corrects the architecture of Netherton syndrome- derived skin grafts. Molecular therapy: the journal of the American Society of Gene Therapy, 2011, 19(2):408-416.