Author(s)

Blunk Dennis

Affiliation(s)

Department of Pharmaceutical Technology, University of Regensburg, Regensburg, Germany.

Corresponding Author

Blunk Dennis

ABSTRACT

In the past decade, colorectal cancer immunotherapy has made great progress, especially for mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) colorectal cancer phenotypes, immunotherapy has sustained therapeutic responses, and achieved significant clinical efficacy. However, most metastatic colorectal cancers are non-mismatch repair deficient (pMMR) or microsatellite stable (MSS), and these patients benefit less from immune checkpoint inhibitors (ICIs). With the widespread development of clinical trials of ICIs in colorectal cancer, immunotherapy has gradually expanded its indications due to its proven efficacy, and has become the standard first-line treatment for patients with dMMR/MSI-H advanced colorectal cancer. For patients with pMMR/MSS, ICIs have also shown potential therapeutic effects by combining chemotherapy and targeted therapy. This article mainly discusses the application of ICIs in colorectal cancer, analyzes the relationship between tumors and the immune system, and outlines the immunological characteristics and classification of colorectal cancer as well as the latest progress of ICIs in the treatment of colorectal cancer.

KEYWORDS

Colorectal tumors; Immune checkpoint inhibitors; Immunity therapy; Biomarkers

CITE THIS PAPER

Blunk Dennis. The relationship between immune checkpoint inhibitors in colorectal cancer. World Journal of Biomedical Sciences. 2024, 2(1): 14-18. DOI: 10.61784/wjbs240143.

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