Author(s)

YongLi Tan^*, YeMu Zhu, HaiFeng Duan

Affiliation(s)

The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, Hunan, China.

Corresponding Author

YongLi Tan

ABSTRACT

While porous materials have been widely employed in numerous fields ranging from gas adsorption and separations, light emittance, sensing to energy storage, their applications in reducing respiratory morbidity are limited. In particular, the products obtained in a controlled manner using porous materials and thus applied to limit lung cancer cells multiplication are very rare. Here we report the synthesis of two new truxenone and isotruxenone-based porous organic polymers (POPs) via Friedel-Crafts alkylation/oxidation starting from truxene and isotruxene. These networks are thermally and chemically stable, and demonstrated as the first metal-free, heterogeneous photocatalysts for visible-light-induced tunable benzylic functionalization. Moreover, both POPs can be easily recovered and reused for at least 15 times without any apparent decrease in their photocatalytic activity. The synthetic utility of this newly-developed methodology is demonstrated in the value-added functionalization of chemical feedstocks such as xylenes and mesitylene, the resulting product can be used to reduce the number of lung cancer A549 cells.

KEYWORDS

A549 cells; Heterogeneous photocatalysis; Metal-Free; Porous polymers; Visible-Light

CITE THIS PAPER

YongLi Tan, YeMu Zhu, HaiFeng Duan. Truxenone and isotruxenone-based porous organic polymers as metal-free, heterogeneous photocatalysts for visible-light-promoted reduction of lung cancer A549 cells. Eurasia Journal of Science and Technology. 2024, 6(2): 51-65. DOI: 10.61784/ejst3007.

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