Author(s)

Qi Wang*, ChangHai Tuo, Fei Fu, Lin Tian*

Affiliation(s)

Department of Pathology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.

Corresponding Author

Qi Wang, Lin Tian

ABSTRACT

Objective: To investigate the expression of transforming growth factor- β (TGF-β) and epithelial membrane protein 1 (EMP-1) in middle and advanced esophageal squamous cell carcinoma (ESCC) and its role on tumor progression, and to define the role of TGF-β and EMP-1 as pro-cancer and tumor suppressors. Methods: The expression levels of TGF-β and EMP-1 in carcinoma and adjacent tissues of 60 ESCC patients. The correlation of both expression was explored by Spearman correlation analysis and their impact on patient outcomes was assessed by Kaplan-Meier survival analysis. Results: TGF-βexpression was significantly higher in ESCC carcinoma tissues than adjacent tissues (P <0.05), while EMP-1 expression was significantly lower in adjacent tissues (P <0.05). The prognosis of patients with high TGF-β expression and low EMP-1 expression was significantly worse than that in the other groups (P <0.05). Conclusions: TGF-β plays a role as a cancer-promoting factor in ESCC, while EMP-1 is downregulated as a tumor suppressor, suggesting the importance of both in cancer progression. Their expression levels can be used as potential markers to predict the prognosis of ESCC patients.

KEYWORDS

Tumor microenvironment; ESCC; Biomarkers; TGF-β; EMP1

CITE THIS PAPER

Qi Wang, ChangHai Tuo, Fei Fu, Lin Tian. Expression and prognostic role of TGF-Β and EMP-1 in intermediate and advanced esophageal squamous cell carcinoma. Journal of Pharmaceutical and Medical Research. 2024, 6(3): 39-44. DOI: 10.61784/jpmr3014.

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