Author(s)

XingChi He

Affiliation(s)

Springfield Commonwealth Academy, Springfield, 01105, USA.

Corresponding Author

XingChi He

ABSTRACT

The incidence of diabetes is increasing, and diabetes has become one of the difficult problems in the medical field. The hyperglycemic environment in diabetic patients can lead to the damage of VEC(vascular endothelial cells) and various abnormal reactions of vascular physiological functions, which can cause diabetic vascular complications and damage the body of diabetic patients. High glucose can up regulate the protein expression of Pin1 (proline isomerase-1) and damage the function of vascular endothelium. Faced with this situation, this paper studied the inhibition of Pin1 by 25-dihydroxyvitamin D3. Studies have shown that 25-dihydroxyvitamin D3 can significantly alleviate the damage of vascular endothelial cells (VEC), and can inhibit the expression level of Pin1 and the phosphorylation level of p66Shc (an oxidative adaptor protein). It can reduce ROS (Reactive Oxygen Species) level and CASP3 (caspase-3) level in vascular endothelial cells. 25-dihydroxyvitamin D3 can inhibit the expression level of Pin1 protein by 9.02% by activating VDR (vitamin D receptor).

KEYWORDS

25-Dihydroxyvitamin D3; Proline isomerase-1; Drug delivery; Diabetic vascular endothelial injury

CITE THIS PAPER

XingChi He. 25-Dihydroxyvitamin D3 alleviates diabetic vascular endothelial injury by inhibiting proline isomerase-1 mediated mitochondrial oxidative stress and inflammation. World Journal of Biomedical Sciences. 2024, 2(2): 26-33. DOI: 10.61784/wjbs3004.

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