Author(s)

RongMing Zhou

Affiliation(s)

JIU ZHI TANG MAKER (Beijing) Cell Technology Co., Ltd, Beijing 102600, China.

Corresponding Author

RongMing Zhou

ABSTRACT

This article explores the application of statistics in cell therapy research, especially in the fields of immunotherapy and neural repair. The article emphasizes the key role of statistical methods in evaluating treatment effects, managing risks, and designing rational clinical trials. Through tools such as survival analysis, hypothesis testing, and statistical models, researchers can intuitively assess patients' survival and progression-free survival, as well as predict treatment effects and adverse reactions. The article also discusses the challenges of randomized controlled trial design, multicenter studies, and the importance of data management and analysis. Finally, the article points out the value and prospects of statistics in cell therapy research, while also proposing the limitations of current research and future directions.

KEYWORDS

Cell therapy; Statistical application; Survival analysis; Hypothesis testing; Randomized controlled trial

CITE THIS PAPER

RongMing Zhou. Application of statistics in the application of cell therapy research. Eurasia Journal of Science and Technology. 2024, 6(5): 7-11. DOI: 10.61784/ejst3030.

REFERENCES

[1] Zu Cheng, Wang Kexin, Zhang Qiqi, et al. Clinical observation of BCMA-targeted chimeric antigen receptor T cell therapy for relapsed/refractory multiple myeloma with hemophagocytic syndrome. Journal of Zhejiang University (Medical Edition), 2022, 51(02):160-166.

[2] Chen Y, Jian T, Shen Y. Immune Checkpoint Inhibitors in Lung Cancer// Wuhan Zhicheng Times Cultural Development Co., Ltd.. Proceedings of 2nd International Conference on Biomedical Engineering, Healthcare and Disease Prevention (BEHDP 2022). Capital Medical University; Guizhou Medical University; Shenzhen College of International Education, 2023: 10.

[3] Guo Huanxu, Fan Dan, Zhang Jingyi, et al. Comparative efficacy of first-line immunosuppression and hematopoietic stem cell transplantation in treating hepatitis-associated aplastic anemia. Journal of Clinical Hematology, 2024, 37(05): 343-348.

[4] Wang Hongjuan, Hu Wen, Ding Yuan, et al. Meta-analysis of efficacy of autologous cell transplantation in the treatment of stable vitiligo. Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine, 2024, 23(01): 22-29.

[5] Liu Yukai, Liu Qi, Ma Cong, et al. Effect of anti-CD19 chimeric antigen receptor T-cell therapy on pediatric acute B-lymphoblastic leukemia. Chinese Medical Innovation, 2023, 20(16): 43-47.

[6] Zhang Zhanqiang, Zhang Gailing, Li Wenqian, et al. Relationship between platelet count and the efficacy of CD19-CAR-T cell therapy in refractory/relapsed acute B lymphoblastic leukemia. Journal of Clinical Hematology, 2022, 35(09): 674-676+679.

[7] Huang Hongyun, Chen Lin, Mao Gengsheng, et al. Progress in clinical cell therapy in neurorestoratology. Chinese Journal of Cellular and Stem Cell Research (Electronic Edition), 2022, 12(01): 1-7.

[8] Wu Qiaozhu, Tian Chunfang. Research progress in the treatment of intrauterine adhesion. Guide to Women and Children's Health, 2024, 3(18): 23-26+30.

[9] Guo X, Sheng X. Drug discovery of PD-L1 inhibitor Atezolizumab// Wuhan Zhicheng Times Cultural Development Co., Ltd.. Proceedings of 2nd International Conference on Biomedical Engineering, Healthcare and Disease Prevention (BEHDP 2022). The university of Strathclyde;The University of Melbourne, 2023: 8.

[10] Xu Xiaoming, Xia Yunlong, Xia Linying, et al. Advances in Non-Pharmacological Treatment of Heart Failure with Preserved Ejection Fraction. Chinese Journal of Interventional Cardiology, 2024, 32 (09): 528-534.

[11] Zhang Weijie, Zhang Hong. Research Progress on the Relationship between Iron Deficiency and Heart Failure. Journal of Cardiovascular and Cerebrovascular Diseases with Integrated Traditional and Western Medicine, 2024, 22 (18): 3343-3346.

[12] Li Zhe, Guo Guangling, Li Ping, et al. Network Meta-Analysis of the Efficacy of Mesenchymal Stem Cells from Different Sources in the Treatment of Animal Models of Premature Ovarian Failure. Chinese Journal of Tissue Engineering Research, 2024 1-12.

[13] Zhao Na, He Sheng, Shi Linan. Effects of 40 Hz Rhythmic Stimulation on Alzheimer's Disease and Cognitive Function. Progress in Biochemistry and Biophysics, 2024, 1-15.

[14] Guo X, Sheng X. Drug discovery of PD-L1 inhibitor Atezolizumab// Wuhan Zhicheng Times Cultural Development Co., Ltd.. Proceedings of 2nd International Conference on Biomedical Engineering, Healthcare and Disease Prevention (BEHDP 2022). The university of Strathclyde;The University of Melbourne, 2023: 8.

[15] Yu Haiyin, Li Xiaoning. Research Progress on Acupuncture Promoting Cell Proliferation and Differentiation after Spinal Cord Injury. Journal of Clinical Acupuncture, 2024, 40 (09): 96-101.

[16] Peng Jianhong, He Jiahua, Liao Leen, et al. Advances in the Clinical Application of Precision Medicine Testing in Hepatic Metastasis of Colorectal Cancer. Chinese ScienceBulletin, 2024, 1-11.

[17] Cao Xiaoshan, Yang Beibei, Cong Binbin, et al. Advances in the Treatment of Brain Metastases in Triple-Negative Breast Cancer. Chinese Journal of Cancer, 2024, 34 (08): 777-784.

[18] Xu Haoran, Zhao Xiaoyi, Nie He, et al. Immunotherapy for Colorectal Cancer. Progress in Biochemistry and Biophysics, 2024, 1-22.

[19] Liu Qing, Su Tingting, Gao Jiaming, et al. Effects of Tianshan Chaopiao on Adipogenic and Osteogenic Differentiation of Adipose-Derived Stem Cells. Journal of Tongji University (Medical Science), 2024, 45 (04): 471-479.

[20] Lin Meiyu, Zhao Xilong, Gao Jing, et al. Mechanisms and Progress of the Anti-Aging Effects of Stem Cells on Ovarian Granulosa Cells. Chinese Journal of Tissue Engineering Research, 2024, 1-8. 

[21] Ying Yu-jia, Tang Yong-min. Analysis of Prognostic Factors and Progress in Treatment of Infant Acute Lymphoblastic Leukemia. Chinese Journal of Pediatric Hematology and Oncology, 2024, 29 (04): 299-302.

[22] Liu Qiang, Liu Hua-qian, Liu Li, et al. Current Status and Prospects of Mesenchymal Stem Cell-Targeted Therapy for Premature Ovarian Insufficiency. Chinese Journal of Cell Biology, 2024, 46 (08): 1567-1579.

[23] Wang Xin-xin, He Ji-hui, Li Gang, et al. Effects of Triclosan on Biological Characteristics of Dental Pulp Stem Cells. Prevention and Treatment of Oral Diseases, 2024, 1-15.

[24] Zheng Zi-ling, Li Yuanyuan, Shan Yuan-hong. Advances in Research on Genetic Doping and Its Detection Technologies// International Bandy Federation (FIB), International Strength and Conditioning Association (ISCA), Macao Strength and Conditioning Association (MSCA), Chinese Bandy Association (CBF). The Proceedings of the 2023 Inaugural International Sports Science Conference by the Chinese Radio Orienteering and Direction Finding Association (CRSOA). Shanghai University of Sport; Shanghai Anti-doping Laboratory, Shanghai University of Sport, 2023: 22.