Author(s)

YiNuo Feng

Affiliation(s)

School of Science, Xi’an Jiaotong-Liverpool University, Suzhou 215000, China.

Corresponding Author

YiNuo Feng

ABSTRACT

The differentiation of epidermal cells is a complex and tightly regulated process that is crucial for maintaining skin barrier function and homeosta. AFF1/FMR2 family member 1 (AFF1) has been shown to be involved in various cellular processes, but its role in epidermal cell differentiation has not been fully elucidated. In this study, we investigated the role of AFF1 in epidermal cell differentiation by analyzing transcriptome data. We found that AFF1 undergoes dynamic regulation of expression during the differentiation of human keratinocytes. AFF1 knockdown significantly upregulates the expression of key transcription factors such as GRHL3, OVOL1, and PRDM1, thereby promoting epidermal cell differentiation. Our findings provide new insights into the mechanisms by which AFF1 regulates epidermal cell differentiation and highlight its potential as a therapeutic target for skin diseases.

KEYWORDS

AFF1; Transcriptome analysis; Differentiation

CITE THIS PAPER

YiNuo Feng. AFF1-dependent regulation of gene expression in epidermal cell differentiation. World Journal of Biomedical Sciences. 2024, 2(2): 43-48. DOI: 10.61784/wjbs3005.

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