Author(s)

Aloy-Amadi Oluchi C.^1*, Luke Chinonso¹, Akujobi Augustine U.², Nwadike Constance N.¹, Edward Ukamaka¹, and Igwilo Anastecia C.³

Affiliation(s)

¹Department of Medical Laboratory Science, Imo State University, Owerri, Nigeria.

²Department of Optometry, Imo State University, Owerri, Nigeria.

³Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.

Corresponding Author

Aloy-Amadi Oluchi C.

ABSTRACT

Diabetes Mellitus is a complex disease characterized by chronic hyperglycemia responsible for complications affecting the kidneys, eyes, peripheral nerves, and micro and macrovascular systems. This study was aimed at evaluating the levels of glycated haemoglobin, platelet count, sodium and potassium in type II diabetes mellitus patients attending federal university teaching hospital, Owerri. All eligible subjects who filled the questionnaire and gave written informed consent for the study period were sampled. The study population consisted of 50 patients diagnosed with diabetes mellitus and an equivalent number of age - matched healthy subjects (50) who served as controls. Seven millilitres of blood samples were collected from the study participants.2 mls was aliquoted into ethylenediaminetetraacetic acid (EDTA) containers and used for platelet counts using nuebauer counting chamber and HBA1c estimation using Fluorescence immunoassay method. 5 mls of blood were dispensed into plain containers and used for sodium and potassium  estimations using Flame emission spectrophotometric method. The results of the tests were analyzed using SPSS version 21. The mean values of HBA1c (9.24±2.63)%, potassium (4.49±0.78) mmol/l and platelets (312766.67±90153.01) cells/μl were significantly increased in the diabetics when compared to controls (4.61±1.21)%,(3.91±0.47)mmol/l and (168906.25±55864.67) cells/μl. The mean value of sodium (127.93±10.32)mmol/l was significantly decreased (p=0.002, p=0.000 and p=0.001) in  the diabetics when compared to controls (139.28±5.97)mmol/l (p=0.001. There was no significant difference in the mean values of HBA1C, sodium, potassium and platelets in male diabetics(9.11±3.01)%, (131.66±12.06)mmol/l, (4.52±1.17)mmol/l and (382716.97±58153.78)cells/μl when compared to female diabetics (9.02±2.99)%, (132.11±4.88)mmol/l, (4.48±0.92)mmol/l and (368696.25±65864.01)cells/ μl. There was a non - significant positive correlation (r=0.19, p=0.318; r=0.33, p=0.072 and r=0.03, p=0.871) of HBAIc with sodium, potassium and platelets in the diabetics. Glycated haemoglobin, potassium and platelets were significantly increased in the diabetic patients. The study proves that estimation of glycated haemoglobin, sodium ion, potassium ion and platelet will be very useful in diabetes mellitus patients with regard to understanding the pathogenesis and to evaluate diabetic complications.

KEYWORDS

Diabetes; Glycated haemoglobin; Platelets; Sodium; Potassium

CITE THIS PAPER

Aloy-Amadi Oluchi C., Luke Chinonso, Akujobi Augustine U., Nwadike Constance N., Edward Ukamaka, and Igwilo Anastecia C. Studies on glycated haemoglobin, platelets, sodium and potassium in type ii diabetes patients attending federal university teaching hospital, owerri, Nigeria. Journal of Pharmaceutical and Medical Research. 2024, 6(4): 10-14. DOI: https://doi.org/10.61784/jpmr3019.

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