Author(s)

Aloy-Amadi Oluchi C.^1*, Oguegbu Victor I.¹, Emeka-Obi Obioma R.², Akogu O.³, Ugwuegbulem Callista O.¹

Affiliation(s)

¹Department of Medical Laboratory Science, Imo State University, Owerri, Nigeria.

²Department of Haematology, College of Medicine, Federal University of Technology, Owerri, Nigeria.

³Department of Optometry, Imo State University, Owerri, Nigeria.

Corresponding Author

Aloy-Amadi Oluchi C.

ABSTRACT

Kidney disease is a condition where the kidneys are damaged and unable to function properly. This study was aimed at investigating the status of erythrocyte sedimentation rate, red cell and platelet indices in patients with chronic kidney disease in Owerri metropolis. A total of fifty (50) subjects who were 18 years and above were recruited for the study. Twenty five (25) patients with chronic kidney disease and twenty five (25) age-matched apparently healthy individuals (controls). Samples were collected aseptically, and prepared by standard methods prior to use. Estimation of Erythrocyte Sedimentation Rate (ESR) was done using Westergren method. Estimations of red cell and platelet indices were done using Bio Maxima BM HEM 3 automated hematology analyzer. This study showed that the mean value of ESR was significantly increased in patients with chronic kidney disease when compared to the healthy controls, while the mean values of MCV, MCH, MCHC, MPV, PCT and PDW were significantly reduced in patients with chronic kidney disease when compared to healthy controls (p=0.000 and 0.015). There was no significant difference in the mean values of RDW and PLT in patients with chronic kidney disease when compared to the healthy controls (p=0.857 and p=0.552). There was no significant difference in the mean values of ESR, MCV, MCH, MCHC, RDW, PLT, MPV, PCT and PDW in male patients suffering from kidney disease when compared to females (p=0.538, p=0.460, p=0.315, p=0.183, p=0.477, p=0.085, p=0.824, p=0.089 and p=0.230). The result clearly indicates that an increase in ESR correlates with a decrease in MCV and PDW. Kidney disease is associated with a significant increase in ESR and a decrease in MCV, MCH, MCHC, MPV and PCT. 

KEYWORDS

Red blood cell; Erythrocyte sedimentation rate; Chronic kidney disease; Red blood cell indices; Platelet indices

CITE THIS PAPER

Aloy-Amadi Oluchi C., Oguegbu Victor I., Emeka-Obi Obioma R., Akogu O., Ugwuegbulem Callista O. Status of erythrocyte sedimentation rate, red cell and platelet indices in patients with chronic kidney disease in Owerri metropolis, Nigeria. World Journal of Clinical Sciences. 2024, 2(2): 49-53. DOI: https://doi.org/10.61784/wjcs3008.

REFERENCES

[1] Csaba PK. Epidemiology of chronic kidney disease: an update 2022. Kidney International Supplement, 2022, 12(1): 7–11.

[2] Harrison M. Erythrocyte sedimentation rate and C-reactive protein. Australian Prescriber, 2015, 38(3): 93–4.

[3] Bray C, Bell LN, Liang H, et al. Erythrocyte Sedimentation Rate and C-reactive Protein Measurements and Their Relevance in Clinical Medicine. World Medical Journal, 2016, 115(6): 317–321.

[4] Yonemoto S, Hamano T, Fujii N, et al. Red cell distribution width and renal outcome in patients with non-dialysis-dependent chronic kidney disease. PLoS One, 2018, 13: 198-825.

[5] Lu YA, Fan PC, Lee CC, et al. Red cell distribution width associated with adverse cardiovascular outcomes in patients with chronic kidney disease. British Medical Council and Nephrology, 2017, 18:361.

[6] Zhang T, Li J, Lin Y, et al. Association Between Red Blood Cell Distribution Width and All-cause Mortality in Chronic Kidney Disease Patients: A Systematic Review and Meta-analysis. Archives of Medical Research, 2017, 48:378-385.

[7] Ju HY, Kim JK, Hur SM, et al. Could mean platelet volume be a promising biomarker of progression of chronic kidney disease? Platelets, 2015, 26:143-7.

[8] Verdoia M, Barbieri L, Schaffer A, et al. Impact of renal function on mean platelet volume and its relationship with coronary artery disease: A single-center cohort study. Novara Atherosclerosis Study (NAS) group - Thrombosis Research, 2016, 141: 139-44.

[9] Schoorl M, Schoorl M, Bartels PCM. Changes in platelet volume, morphology and RNA content in subjects treated with hemodialysis. Scandinavian Journal of Clinical Laboratory Investigation. 2018, 68: 335-42.

[10] Gasparyan AY, Ayvazyan L, Mikhailidis DP, et al. Mean Platelet Volume: a link between thrombosis and inflammation. Current Pharmacological Dissertation, 2021, 17: 47 – 58.

[11] Murphy D. World Kidney Day 2016: Averting the Legacy of Kidney Disease - Focus on Childhood. Acta Paediatrica, 2016, 105(4): 407-409.

[12] Levey A S, Coresh J. Chronic Kidney Disease. The Lancet, 2012, 379(9811): 165–180.

[13] Maradit-Kremers H, Nicola P, Crowson C, et al. Raised erythrocyte sedimentation rate signals heart failure in patients with rheumatoid arthritis. Annals of Rheumatoid Disorder, 2017, 66: 76–80.

[14] Beighton P, Solomon L, Valkenburg H. Rheumatoid arthritis in a rural South African Negro population. Annals of Rheumatologic Discussions, 2015, 34(2): 136-141.

[15] Blix M, Hedin S. Haematocrit. Analtical Journal, 2017, 30(1): 652-654.

[16] Erken E, Ulgen C, Sarisik FN, et al. Hematological Parameters and Clinical Features in Patients with Advanced Chronic Kidney Disease. Yonago Actarial Medicine, 2020, 1063(4): 353-359.

[17] Habib A, Ahmad R, Rehman S. Hematological changes in patients of chronic renal failure and the effect of hemodialysis on these parameters. International Journal of Research in Medical Science, 2017, 5(11): 4998-5003.

[18] Cozzolino M, Mangano M, Stucchi A, et al. Cardiovascular disease in dialysis patients; Nephrology Dialysis Transplantation, 2018, 33 (3): 28 -34.

[19] Shankar A, Klein E. and Klein R.,(2014). Relationship between white blood cell count and incident hypertension;; American Journal of Hypertension; 17: 233 – 239.