Author(s)

Rando Grace

Affiliation(s)

University of London, London, WC1E6bt, England.

Corresponding Author

Rando Grace

ABSTRACT

Major Depressive Disorder (MDD) is a severe mental disorder with approximately 350 million patients worldwide. In recent years, oxidative stress has played an important role in the pathogenesis of depression. This study used bioinformatics methods to explore the expression patterns of oxidative stress-related differential genes in MDD and screen related traditional Chinese medicines, in order to provide more reference for clinical decision-making.

KEYWORDS

Severe depression; Oxidative stress; Traditional Chinese medicine screening; Ginseng; tea tree root; Saffron

CITE THIS PAPER

Rando Grace. Analysis of oxidative stress-related genes in major depression based on bioinformatics and screening of targeted prevention and treatment of traditional Chinese medicines. Integrative Bioinformatics. 2024, 1(1): 1-4. DOI: https://doi.org/10.61784/ib3002.

REFERENCES

[1] Wu Zhenning, Wang Qi, Qin Xuemei, et al. Research progress on intestinal flora and its metabolites in the treatment of depression with traditional Chinese medicine. Chinese Herbal Medicine, 2023, 54(14): 4713-4722.

[2] Ga?ecki P, Szemraj J, Bieńkiewicz M, et al. Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment. Pharmacol Rep, 2009, 61(3): 436-447.

[3] Maes M, Galecki P, Chang Y S, et al. A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog Neuro Psychopharmacol Biol Psychiatry, 2011, 35(3): 676-692.

[4] Zhang Y L, Long Y, Yu S, et al. Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder. Pharmacol Res, 2021, 164: 105376.

[5] Zhuang W, Liu S L, Xi S Y, et al. Traditional Chinese medicine decoctions and Chinese patent medicines for the treatment of depression: Efficacies and mechanisms. J Ethnopharmacol, 2023, 307: 116272.

[6] Chang L C, Jamain S, Lin C W, et al. A conserved BDNF glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies. PLoS One, 2014, 9(3): e90980.

[7] Stelzer G, Rosen N, Plaschkes I, et al. The GeneCards suite: From gene data mining to disease genome sequence analyzes. Curr Protoc Bioinformatics, 2016, 54: 1.30.1-1.30.1.30.33.

[8] deficit in asthmatic patients with depression. J Asthma, 2022, 59(2): 288-296.

[9] Dang X L, Song M, Lv L X, et al. Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders. Hum Genet, 2023, 142(6): 809-818.

[10] Peres D S, Theisen M C, Fialho M F P, et al. TRPA1 involvement in depression- and anxiety-like behaviors in a progressive multiple sclerosis model in mice. Brain Res Bull, 2021, 175: 1-15.

[11] Tian Y, Chen X Y, Wang Y, et al. Neuroinflammatory transcriptional signatures in the entorhinal cortex based on lipopolysaccharide-induced depression model in mice. Biochem Biophys Res Commun, 2022, 590: 109-116.

[12] Boda E. Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress-related disorders. Eur J Neurosci. 2021, 53(1):281-297.

[13] Gutierrez-Rodelo C, Martinez-Tolibia S E, Morales Figueroa G E, et al. Modulating cyclic nucleotides pathways by bioactive compounds in combatting anxiety and depression disorders. Mol Biol Rep, 2023, 50(9): 7797-7814.

[14] Whyte A, Jessen T, Varney S, et al. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochem Int, 2014, 73: 122-126.

[15] Solis-Ortiz S, Arriaga-Avila V, Trejo-Bahena A, et al. Deficiency in the essential amino acids l-Isoleucine, l-Leucine and l-Histidine and clinical measures as predictors of moderate depression in elderly women: A discriminant analysis study . Nutrients, 2021, 13(11):3875.

[16] Schroeder F. Altered phospholipid composition affects endocytosis in cultured LM fibroblasts. Biochim Biophys Acta, 1981, 649(2): 162-174.